Process Development Engineering Scientist

Job Description

General Summary:

Vertex is seeking a Scientist to join our Process Development group. This group offers a dynamic fast-paced and highly collaborative environment to make an impact. Our team focuses on bringing together the best process design scale-up and cutting-edge manufacturing technologies to enable the successful implementation of cell and gene therapeutics.

The Process Development scientist is a bench-focused position responsible for the design and development of a robust scale-up process for cell therapy products. The scientist will collaborate closely with analytical development technology transfer manufacturing science and technology internal manufacturing CDMOs and other internal and external partners to design and implement robust scalable and phase-appropriate manufacturing processes that enable clinical and commercial supply.

Key Responsibilities:

• Lead the design execution and analysis of experiments to develop robust scalable manufacturing processes for cell therapy programs.

• Develop robust scale-up process of bioreactor and cell processing for cell therapy.

• Drive optimization of cell culture processes including media screening feed strategies culture parameters optimization in stirred-tank bioreactor systems.

• Evaluate and implement emerging technologies to advance cell therapy products process development.

• Applystatistical toolsand QbD principles to guide process optimization and characterization.

• Supporttechnology transferactivities to internal and external manufacturing sites including on-site technical support as needed.

• Author and review CMC sections of regulatory filings as well as technical protocols batch records development reports and standard operating procedures (SOPs).

Required Qualifications:

• Degree in Chemical Engineering Biomedical Engineering Biology or a related field. PhDwith 0 to 3 years of industry experience; Mastersdegree with 5 years of industry experience or Bachelorsdegree with 6 years of industry experience

• Hands-on experience in stirred tank bioreactor operation and scale-up development in fed-batch and/or perfusion mode. Or hands-on experience in cell processing systems operation and scale-up development. (Prior experience in stem cell or stem cell derived products cell culture and/or cell processing is highly desirable.

• Demonstrated proficiency instatistical tools (e.g. JMP) and their application to experimental design process optimization and process characterization

• Highly self-motivated proactive and adaptable with a passion for scientific problem-solving

• Excellent communication collaboration and time management skills

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Pay Range:

Disclosure Statement:

Flex Designation:

Flex Eligibility Status:

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a persons race color sex gender identity or expression age religion national origin ancestry ethnicity disability veteran status genetic information sexual orientation marital status or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager or contact Talent Acquisition at