Translational Biologist / Senior Translational Biologist, London

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights faster breakthroughs and life-changing medicines with an ambition to solve all disease.

The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured starting with better and faster drug discovery.

Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals while being a part of an inspiring and collaborative culture.

The world we want tomorrow is the one were building today. It starts with the culture at this company. It starts with you.

About Iso

Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Since then our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed.

Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AIs powerful capabilities we can use it to model complex biological phenomena to help design novel molecules anticipate how drugs will perform and develop innovative medicines to treat and cure some of the worlds most devastating diseases.

We have built a world-leading drug design engine comprising AI models that are capable of working across multiple therapeutic areas and drug modalities. We are continually innovating on model architecture and developing cutting-edge capabilities to advance rational drug design.

Every day and with each new breakthrough were getting closer to the promise of digital biology and achieving our ambitious mission to one day solve all disease with the help of AI.

Your impact

Isomorphic labs are seeking exceptional individuals to join an impactful translational biology sub team within our translational science team working in multidisciplinary ML-based drug discovery medical research.

These roles would be ideal for experienced translational biologists with a skill for designing fit-for-purpose screening cascades to provide robust experimental evidence that our ML-designed medicines will have the desired therapeutic product profiles (TPPs).This is an exciting opportunity to work closely with world leading AI ML and drug design experts to develop imaginative new ways to test biological hypotheses building a deep mechanistic understanding of drug target interactions in disease to drive our projects forward. You will be responsible for establishing and implementing translational strategies advancing our oncology immunology and partnership portfolios from early drug discovery through to candidate selection and ultimately to clinical phase work. You will have experience of working broadly across drug discovery projects and have the ability to think originally and critically knowing when to apply innovative ideas and think with a beginners approach.

What you will do

• Contribute to biological screening cascades for a variety of internal and partnered drug design programs with a focus on translation of preclinical studies into clinical efficacy in the target patient population.
• Play a critical role in defining the most appropriate model paradigm (in vivo ex-vivo patient derived tissue etc) for each projects translational package including developing a biomarker strategy to deliver early clinical proof of concept.
• Work with CROs to design decision-making experiments and deliver the highest quality biological data to inform the path to the clinic.
• Provide scientific expertise to the AI/ML/computational biology teams to support the development of world-leading models of biological systems.
• Distil biological data into useful insights and recommendations for project leaders project team members and partners.
• Be closely integrated within or lead projects to provide strategic input to deliver project success.
• Contribute relevant internal and supporting regulatory documentation for preclinical and clinical work.
• Work cross-functionally with the Drug Design and Technology teams.

Skills and qualifications

Essential:

• BSc MSc or PhD in a relevant field of biology.
• Deep understanding of target mechanism and disease interdependencies preferably in oncology or immunology.
• Expert knowledge of innovative translational models particularly in oncology and/or immune disorders.
• Extensive pharma/biotech experience developing Target Product Profiles (TPPs) and converting them into biological screening cascades to guide impactful drug development.
• Proven track record in constructing translational data packages and biomarker strategies to inform clinical trial design.
• Experience in designing PK/PD experiments for human dose prediction and collaborating with ADMET formulation and clinical specialists to refine strategies.
• Ability to phase translational biology activities collaboratively considering interdependencies to generate relevant data efficiently.
• Experience working with CROs in acquiring and interpreting high quality biological data in a timely manner.
• Dynamic agile and flexible individual who can work across many projects therapeutic areas and multi-disciplinary teams.
• Effective communication across a broad interdisciplinary team working with key stakeholders with different skills and backgrounds.

Nice to have:

• Experience in project leadership or leading biology within drug discovery programs ideally from inception to clinical candidate delivery.
• Track record of driving strategic de-risking and SAR strategies collaborating effectively across disciplines including medicinal chemistry and DMPK. Good understanding of medicinal chemistry concepts.
• General knowledge of machine learning modelling applied to biological systems and drug discovery.
• Solid understanding of the competitive landscape in oncology and/or immunology or inflammation.
• Experience in target identification validation and selection approaches.

Culture and values

We are guided by our shared values. Its not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it.

Thoughtful
Thoughtful at Iso is about curiosity creativity and care. It is about good people doing good rigorous and future-making science every single day.

Brave
Brave at Iso is about fearlessness but its also about initiative and integrity. The scale of the challenge demands nothing less.

Determined
Determined at Iso is the way we pursue our goal. Its a confidence in our hypothesis as well as the urgency and agility needed to deliver on it. Because disease wont wait so neither should we.

Together
Together at Iso is about connection collaboration across fields and catalytic relationships. Its knowing that transformation is a group project and remembering that what were doing will have a real impact on real people everywhere.

Creating an extraordinary company

We believe that to be successful we need a team with a range of skills and talents. Were building an environment where collaboration is fundamental learning is shared and every employee feels supported and able to thrive. We value unique experiences knowledge backgrounds and perspectives and harness these qualities to create extraordinary impact.

We are committed to equal employment opportunities regardless of sex race religion or belief ethnic or national origin disability age citizenship marital domestic or civil partnership status sexual orientation gender identity pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law. If you have a disability or additional need that requires accommodation please do not hesitate to let us know.

Hybrid working

Its hugely important for us to share knowledge and build strong relationships with each other and we find it easier to do this if we spend time together in person. This is why we follow a hybrid model and would require you to be able to come into the office 3 days a week (currently Tuesday Wednesday and one other day depending on which team youre in). If you have additional needs that would prevent you from following this hybrid approach wed be happy to talk through these if youre selected for an initial screening call.

Please note that when you submit an application your data will be processed in line with our .

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