Scientist - Ex Vivo & 3D Model Assays
Scientist - Ex Vivo & 3D Model Assays
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Job Description
Job Title: Scientist Ex Vivo & 3D Model Assays
Location: Natick MA
Department: Integrated Discovery Unit
Position Type: Full-Time
Job Summary:
We are seeking a highly motivated Scientist with hands-on expertise in ex vivo immune assays 3D spheroid and organoid-based platforms to support our preclinical drug discovery efforts. The successful candidate will have a PhD with 1-2 yrs or Masters degree with 34 years of relevant industry experience and will play a key role in evaluating the biological activity and mechanism of novel therapeutic candidates across oncology autoimmune and inflammatory disease areas.
This role is ideal for a scientist passionate about translating complex biology into meaningful data using patient-relevant assay systems.
Key Responsibilities:
- Design execute and analyze ex vivo assays using human PBMCs tumor digests or tissue-derived immune cells.
- Develop and implement 3D spheroid and organoid-based co-culture systems including tumor-immune or stroma-immune models.
- Perform high-content immunophenotyping and functional readouts using multi-color flow cytometry cytokine profiling (MSD ELISA Luminex) and live-cell imaging.
- Support pharmacodynamic MOA and efficacy studies for biologics TCEs and other immunomodulatory agents.
- Work with human biospecimens (e.g. tumor tissue blood ascites) and maintain compliance with biosafety and sample handling protocols.
- Maintain detailed records present findings at team meetings and contribute to internal documentation and publications.
Qualifications:
- PhD in Immunology Cell Biology Pharmacology or a related field with 12 years of hands-on industry experience or a Masters degree with 34 years of relevant experience in a biotechnology or pharmaceutical setting.
- Proven expertise in ex vivo immune cell assays primary cell culture and immune cell functional analysis.
- Experience with 3D cell culture systems such as tumor spheroids organoids or co-culture models.
- Strong skills in flow cytometry (data acquisition and analysis) cytokine assays and viability/proliferation platforms.
- Familiarity with handling human tissue samples and BSL-2 laboratory practices.
- Excellent organizational skills attention to detail and the ability to independently troubleshoot and optimize assays.
- Strong team player with effective communication and presentation skills.
Preferred Qualifications:
- Experience applying 3D culture platforms to immune-oncology autoimmune disease or ither disease area.
- Proficiency in flow cytometry software (e.g. FlowJo) imaging platforms (e.g. Incucyte) and analysis tools (e.g. GraphPad Prism).
- Knowledge of T cell biology myeloid interactions or tumor microenvironment.
- Familiarity with antibody-based therapeutic formats including T cell engagers ADCs or bispecifics.
The Anticipated pay range for position is $60000-$1000000
The job description does not intend to list all the duties and responsibilities assigned to this position. Employee holding this position would be required to perform other job-related duties/responsibilities based on their expertise and company business needs.
Employment Type
Full Time
