Senior Scientist, Chemoproteomics
Senior Scientist, Chemoproteomics
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$ 90900 - 151500
1 Vacancy
Job Description
Use Your Power for Purpose
At Pfizer we deliver breakthroughs that change patients La Jolla we are dedicated to the development of oncology agents that disrupt cancer biology or redirect the immune system against cancer cells. The Systems Biology team plays a vital role in this mission through enabling the discovery and molecular understanding of small-molecule therapeutics and novel payload antibody drug conjugates (ADCs).
POSITION SUMMARY
As a Senior Scientist on our Systems Biology team your research will drive a deeper understanding of the mechanism of action of our molecules and cellular targets. You will act as a Chemoproteomics subject matter expert and participate in project teams providing insight and technical expertise required for project progression. You will also work closely with the Medicinal Chemistry Biochemistry and Oncology Biology groups to innovate and develop the next generation of small-molecule and antibody-drug conjugate therapies.
KEY RESPONSIBILITIES
Develop and deploy innovative chemical biology tools with an emphasis on unbiased proteomic technologies to advance portfolio projects.
Enable small-molecule discovery and hit-to-lead through collaborations with biologists and chemists
Actively contribute to multi-disciplinary project teams including developing experimental plans and communication of results
Deploy state-of-the-art chemical biology technologies for target engagement and interactome mapping through chemical probes thermal stability (CETSA) and proximity methods.
Enhance the external reputation of Pfizers Chemical Biology capabilities through publications and presentations at leading conferences
Drive innovation in all aspects of laboratory operations including sample preparation running samples on mass spectrometers data analysis and interpretation.
MINUMUM REQUIREMENTS
PhD in Biological Sciences Chemical Biology Proteomics or a related field.
Experience and proficiency with protein biochemistry techniques (e.g. subcellular fractionation western blot in-gel fluorescence).
Familiarity with biorthogonal chemistry (click) site-selective protein modification photoprobes and activity-based protein profiling (ABPP).
Experience with proteomic workflows and data analysis
Excellent verbal and written communication skills.
Examples of peer-reviewed publications from scientific work to date
Experience working in teams of scientists to deliver objectives
PREFERRED REQUIREMENTS
Relevant PhD degree with 3 years of relevant postdoctoral and/or industry research experience.
Experience with data-independent acquisition (DIA) with data processing utilizing DIANN or Spectronaut.
Experience with automated sample preparation (Bravo AssayMAP Kingfisher).
Demonstrated knowledge of oncology and discovery of small-molecule therapeutics.
Work Location Assignment:Hybrid
The annual base salary for this position ranges from $90900.00 to $151500.00. In addition this position is eligible for participation in Pfizers Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of lifes moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution paid vacation holiday and personal days paid caregiver/parental and medical leave and health benefits to include medical prescription drug dental and vision coverage. Learn more at Pfizer Candidate Site U.S. Benefits (). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race color religion sex sexual orientation age gender identity or gender expression national origin disability or veteran status. Pfizer also complies with all applicable national state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
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Required Experience:
Senior IC
Employment Type
Full-Time
