PhD on Continuous Real-Time Biomolecular Sensing with Single-Molecule Resolution
PhD on Continuous Real-Time Biomolecular Sensing with Single-Molecule Resolution
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Job Description
Departments Department of Biomedical Engineering
Eindhoven University of Technology is an internationally top-ranking university in the Netherlands that combines scientific curiosity with a hands-on attitude. Our spirit of collaboration translates into an open culture and a top-five position in collaborating with advanced industries. Fundamental knowledge enables us to design solutions for the highly complex problems of today and tomorrow.
The Department of Biomedical Engineering offers top-level education and research in one of the most relevant and exciting scientific disciplines of the 21st century: engineering combining engineering and life sciences through challenge-based learning and a multidisciplinary approach in collaboration with hospitals industry and others the department addresses the great challenges of the future striving to improve healthcare and society as a whole.
Introduction
Are you eager to develop a new biosensing technology for continuous real-time monitoring of molecules like pharmaceutical drugs and inflammatory biomarkers Join us in tackling this challenge!
Job Description
Continuous sensors are available in society and are used by patients to monitor their glucose levels. However continuous sensing is not yet available for monitoring low-concentration molecules such as proteins drugs and nucleic acids. Thats what we want to achieve!
The sensing technologies that are being developed in the Molecular Biosensing group (MBx see are unique in the world. The sensors are based on reversible single-molecule interactions for the continuous monitoring of biomolecules at low concentrations. The sensing platform is called Biosensing by Particle Motion (BPM) using particles on a sensing surface that change their motion due to the binding of analyte molecules.
In your PhD project you will study biomolecular aspects of BPM sensors such as affinity binders and conjugation strategies in order to determine how these affect the sensor performance. The PhD project is part of the iControl collaboration that includes TU Eindhoven Erasmus Medical Center Leiden Academic Center for Drug Research and several companies ( Publications about the BPM sensing technology are listed on MBx group has trans-disciplinary research approaches including molecular bioengineering advanced data analysis and optical microscopies. The MBx group initiated and organizes the international competition on Sensors for Health () and the international symposium on Continuous Real-time Biomolecular Sensing ( Laboratories are shared with the Protein Engineering research group ( and the Institute for Complex Molecular Systems ( Requirements Do you recognize yourself in this profile and would you like to know more Please contact the hiring manager Prof. M.W.J. Prins () and Dr. A.M. de Jong (). Visit our website for more information about the application process or the conditions of employment. Are you inspired and would like to know more about working at TU/e Please visit our career page. We invite you to submit a complete application by using the apply button. Only complete applications will be considered. We look forward to receiving your application and will screen it as soon as possible. The vacancy will remain open until the position is filled.Conditions of Employment
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Employment Type
Full-Time
