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Researcher
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Job Description
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Job Title:
ResearcherDepartment:
CCC Sponsored ResearchResearcher Job Description in Cancer Biology
School:Department of Internal Medicine The Ohio State University.
Description:We are seeking highly motivated and enthusiastic Ph.D. or MD scientists to join our group as postdoctoral research fellows.
We are now accepting applications for a Researcher position in the laboratory of Dr. Triparna Sen at the Department of Internal Medicine Division of Medical Oncology at The Ohio State University.
Dr. Sen is a Professor in the Department of Internal Medicine at The Ohio State University. The Sen lab aims to achieve a systematic and comprehensive understanding of the mechanisms of initiation progression and therapeutic resistance in lung cancer. The lab has established the use of multiple high-throughput screening technologies genomics proteomics metabolomics clinical samples and animal models to accomplish these goals. The results will lead to the development of novel therapeutic strategies for the clinically relevant molecular subsets of lung cancer.
Position Summary:
The Researcher will be a core technical member of the lab supporting all aspects of translational research with a focus on:
- CRISPR screening platforms
- Drug dosing studies in both in vitro and in vivo settings
- Clinical sample processing including the development of patient-derived xenograft (PDX) models
The successful candidate will work closely with postdoctoral fellows and other technical staff and play an integral role in executing experiments maintaining research infrastructure and supporting the broader goals of the lab.
Responsibilities:
- Design and execute CRISPR-Cas9-based genetic screens in lung cancer cell models
- Culture and manipulate human lung cancer cell lines and organoids including transfections and viral transductions
- Perform drug sensitivity assays in vitro and conduct dosing studies in mouse xenograft models
- Establish and maintain PDX and CDX models using immunocompromised mouse strains (NSG NRG athymic nude)
- Process human lung tissue specimens for downstream molecular and cellular analyses including:
- RNA/protein extraction
- Flow cytometry and cell sorting
- Single-cell suspensions for sequencing or culture
- Operate lab equipment including GentleMACS Cell Dissociator flow cytometers biosafety cabinets and centrifuges
- Coordinate mouse studies: monitor health measure tumor burden maintain accurate animal records in compliance with IACUC protocols
- Prepare experimental reagents solutions and maintain lab stocks
- Organize and update biobank/sample databases and maintain meticulous experimental records in ELN or lab notebooks
- Assist in procurement of lab reagents and equipment; coordinate with administrative staff for ordering and service contracts
Required Qualifications:
- Master of Science Degree in Life Sciences or a related field.
- 5 years of relevant lab experience preferably (but not limited to) in cancer biology.
- Proficiency in cell culture and standard molecular biology techniques.
- Experience handling mice including tumor implantation and drug administration is a requirement for this position.
- Excellent interpersonal skills problem-solving flexibility and adaptability able to interface with lab staff.
- Adept at planning and prioritizing work to meet commitments with a keen eye for detail.
- Action-oriented and eager to take on new opportunities and tough challenges with a sense of urgency high energy and enthusiasm.
Application Requirements: In addition to workday application requirements.
Please upload as a single PDF file by September 15 2025:
- Cover letter (maximum 2 pages) indicating research background interest in the position and expected start date
- Curriculum Vitae (CV)
- Reprints or PDFs of up to two relevant publications (if available)
- Names and contact information of three professional references
Principal Investigator:
Dr. Triparna Sen
Professor Department of Internal Medicine
Associate Director of Research Division of Medical Oncology
Director Preclinical Therapeutics Platform
The Ohio State University
The Arthur G. James Comprehensive Cancer Center
508 Biomedical Research Tower
460 W 12Th Ave Columbus OH 43210
Function: Research and Scholarship
Sub Function: Research
Career Band: Individual Contributor - Specialized
Career Level: S3
Additional Information:
The Ohio State University is a dynamic community of diverse resources where opportunity thrives and where individuals transform themselves and the world. The Ohio State University is one of the nations largest and most comprehensive public universities and a top employer in Ohio.
As one of only 54 designated comprehensive cancer centers in the nation The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute is dedicated to the creation of knowledge in laboratory clinical and population-based cancer research. We apply those discoveries to develop more effective approaches to cancer prevention diagnosis and therapies providing tomorrows standard of care today. A Cancer-Free World Begins Here.
The OSUCCC James is the only cancer program in the United States that features a National Cancer Institute (NCI)-designated comprehensive cancer center aligned with a nationally ranked academic medical center and a freestanding cancer hospital on the campus of one of the nations largest public universities. is the only cancer program in the United States that features a National Cancer Institute (NCI)-designated comprehensive cancer center aligned with a nationally ranked academic medical center and a freestanding cancer hospital on the campus of one of the nations largest public universities.
Location:
Biomedical Research Tower (0112)Position Type:
RegularScheduled Hours:
40Shift:
First ShiftFinal candidates are subject to successful completion of a background check. A drug screen or physical may be required during the post offer process.
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The university is an equal opportunity employer including veterans and disability.
As required by Ohio Revised Code section 3345.0216 Ohio State will: educate students by means of free open and rigorous intellectual inquiry to seek the truth; equip students with the opportunity to develop intellectual skills to reach their own informed conclusions; not require favor disfavor or prohibit speech or lawful assembly; create a community dedicated to an ethic of civil and free inquiry which respects the autonomy of each member supports individual capacities for growth and tolerates differences in opinion; treat all faculty staff and students as individuals hold them to equal standards and provide equality of opportunity with regard to race ethnicity religion sex sexual orientation gender identity or gender expression.
Employment Type
Full-Time
