Associate Principal Scientist Pharmacology (Clinical) - Cell Therapy
Associate Principal Scientist Pharmacology (Clinical) - Cell Therapy
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$ 135457 - 203186
1 Vacancy
Job Description
Position Summary:
The Clinical Pharmacologist is a scientific role that works with the project team to create clinical pharmacology development plans providing a clear strategy towards the right dose to patients. You will also design conduct analyze and interpret results from Clinical Pharmacology studies to support decisions at study and project level.
You will ensure state-of-the-art Clinical Pharmacology and Model-Informed Drug Development (MIDD) approaches are implemented to support AstraZenecas cell therapy pipeline. Working closely with Pharmacometrician colleagues you will oversee the development and delivery of analyzes that leverage foundational and cutting-edge pharmacometrics modeling techniques in combination with business domain knowledge to develop and apply advanced pharmacometrics modeling to clinical projects.
Responsibilities:
Lead clinical pharmacology activities for assigned projects
Use modeling and simulation to support decision making and dose selection
Prepare relevant sections of clinical study protocols reports and regulatory documents
Accountable for expert data integration analysis interpretation and reporting of clinical pharmacology results at the study level to support project (project team/governance)
Contribute to regulatory documents and interactions (written and oral)
Present clinical pharmacology results to internal and external forums
Contribute to internal projects to develop the clinical pharmacology discipline including its processes
Compliance with Good Clinical Practice (GCP) regulations and internal/external guidances
Education and Experience:
PhD or equivalent in pharmacokinetics pharmaceutical sciences or a related discipline
Experience of pharmacokinetics and Model-Informed Drug Development (MIDD)
3-6 Years of industry drug development experience in clinical pharmacology to support decision-making dose selection study design and regulatory interactions
Hands on experience and advanced proficiency in using clinical pharmacology software including NONMEM R Phoenix WinNonlin
Be able to work in a matrix team environment and influence the team with a data-driven approach
Knowledge of global regulatory compliance processes standards and issues specific to clinical pharmacology
Relevant regulatory experience
Prior cell therapy clinical pharmacology experience
Experience in early and late-stage drug development
The annual base salary for this position ranges from $135457.60 - $203186.40. However base pay offered may vary depending on multiple individualized factors including market location job-related knowledge skills and addition our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles) to receive a retirement contribution (hourly roles) and commission payment eligibility (sales roles).
Our Benefits:
Benefits offered include:
A qualified retirement program 401(k) plan
Paid vacation holidays and paid leaves
Health benefits including medical prescription drug dental and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment.
#celltherapy #LI-Onsite
Date Posted
01-Aug-2025Closing Date
21-Aug-2025Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and furtherance of that mission we welcome and consider applications from all qualified candidates regardless of their protected characteristics. If you have a disability or special need that requires accommodation please complete the corresponding section in the application form.
Required Experience:
Staff IC
Employment Type
Full-Time
