Research Scientist Protein Mass Spec
Research Scientist Protein Mass Spec
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Job Description
Job Description
Vertex is currently seeking a highly motivated Research Scientist with a strong background in Mass Spectrometry (MS) and proteomics to join ourProtein MSteamin our Structural Biology and BiophysicsDepartmentin Oxford supports projectsfrom early stage through to preclinical and providesa global capability instate-of-the-art protein mass position requires experience in the design preparation execution and analysis of unbiased proteomics and targeted quantitative protein/peptide assays to interrogate disease biology and enable small molecule drug discovery. Excellent communication skills are required as is a strong ability to work in a team. Experience with other MS techniques such as small molecule Intact Mass Native HDX or PTM characterisation would be desirable.
As a key player within avibrant andexpanding multi-disciplinary drug discovery team you will be exposed to every aspect of drug discovery and development in one of the worlds leading biotechnology companies.
Key responsibilities:
- Design and execute novel quantitative mass spectrometry assays for peptides and proteomics including analysis of protein PTMs (e.g. glycosylation ubiquitination).
- Design develop and optimize methods in chemoproteomics to identify small molecule target engagement.
- Develop and optimize workflows from sample preparation to data acquisition and data analysis including statistical analysis.
- Work across multiple MS techniques (protein characterisation small molecule peptide mapping)
- Support runningof MS instruments andtake responsibility forroutine upkeep.
- Deliver results in a fast-paced and dynamic research environment and be willing to learn new techniques and technologies as required by the role.
- Organise record and report results according to data integrity guidelines.
- Interpret and explain results to cross-functional teams.
Key Requirements
Essential:
- Relevant Ph.D. or equivalent experience with proven track record of mass spec delivery
- Demonstrated track record of method development and application of common proteomics and MS acquisition and labelling techniques such as PRM DDA DIA LFQ SILAC TMT dimethyl etc
- Experience with data analysis software packages such as MaxQuant Skyline DIA-NN Spectronaut.
- Practical experience working with a variety of MS systems experience with Thermo Orbitrap instruments is essential.
- Hands-on experience troubleshooting complex instrumentation.
- Experience with sample prep peptide enrichment and mass spectrometry method development and optimisation.
- Ability to comfortably manipulate analyse and interpret complex data.
- Self-driven ability to organize resources and data manage time and priorities.
- Desire to work in a fast collaborative and team-oriented environment.
- The ability to communicate clear and concise updates across a variety of audience levels keep track of experimental records and results.
- Demonstrated ability to work as part of a multidisciplinary team.
Desirable
- Familiarity with other protein MS techniques such as Intact Mass Native HDX MS Imaging.
- Experience with glycoproteomics or glycomics methods.
- Experience running and analysing quantitative small molecule mass spec assays.
- Demonstrable leadership for promoting innovation in those techniques and to troubleshoot problems as they arise
- Experience of working within the drug discovery industry
Flex Designation:
On-Site DesignatedFlex Eligibility Status:
In this On-Site designated role you will work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertexs Policy on Flex @ Vertex Program and may be changed at any time.
Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a persons race color sex gender identity or expression age religion national origin ancestry ethnicity disability veteran status genetic information sexual orientation marital status or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager or contact Talent Acquisition at
Employment Type
Full-Time
