Stem Cell Senior Principal Research Associate
Stem Cell Senior Principal Research Associate
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Job Description
Job Description
General Summary:
Vertex seeks a talented scientist to join the Vertex Cell and Genetic Therapies (VCGT) Stem Cell Engineering & Automation team at The Jeffrey Leiden Center for Cell and Genetic Therapies in Boston MA. The teams mission is to discover and actualize the next generation of cell therapies for patients with type 1 diabetes sickle cell disease and Duchenne muscular dystrophy. We are looking for a candidate with an interest in stem cell culture gene editing automation and familiarity with analytical methods in cellular & molecular biology to support VCGTs Stem Cell Editing Platform. The candidate will work closely with our scientists on discovery projects advancing our capabilities in pluripotent stem biology gene editing and immunology. The ideal candidate is scientifically curious accustomed to taking initiative while working with supervisor in setting objectives and may take some responsibility for some experimental design. The position requires keen attention to detail and documentation strong communication and organization skills but also proven adaptability and multitasking capability.
Key Responsibilities:
- Perform human pluripotent stem cell culture gene editing cloning and characterization to support stem cell line development efforts to generate next-generation cell therapies.
- Operate cutting-edge lab equipment including various automation equipment for stem cell culture clonal isolation cryopreservation and characterization.
- Follow detailed protocols and contribute to stem cell line development campaigns (periodic weekend work is required).
- Work with cross-functional teams to plan coordinate and execute experiments.
- Present findings to group and broader research teams summarize data into reports for supervisor.
- Assist with lab management: track cell culture reagents place orders prepare media and reagents demonstrate scientific curiosity to improve lab operations.
- Performs other duties as assigned
Scientific and Non-scientific Skills:
- Pluripotent stem cell culture experience (e.g. hESC and/or hiPSC). Aseptic technique with 2D culture experience is required and 3D is desirable.
- Experience with lab automation including automated liquid handling (Hamilton Biomek etc.) and familiarity with cGMP compliance is desirable but not required.
- Successful candidate will be a team-player with outstanding organization and multitasking capability.
- Familiarity with stem cell characterization assays such as flow cytometry ddPCR DNA sequencing
- Must possess critical thinking keen attention to detail and self-reliance to solve tasks independently or ask questions.
- Experience performing stem cell differentiation and bioreactor operation is desirable but not required.
- Candidate must possess flexibility to quickly pivot as projects demand.
- The candidate will be accustomed to effectively communicating progress needs and problems.
Preferred Education and Experience Levels:
- Masters degree (or equivalent degree) in biological sciences and 2 years of relevant employment experience or
- Bachelors Degree (or equivalent degree) in biological sciences and 5 years of relevant employment experience
Pay Range:
$87300 - $131000Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors including skills competencies experience and other job-related factors permitted by law.
At Vertex our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career financial family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter) educational assistance programs including student loan repayment a generous commuting subsidy matching charitable donations 401(k) and so much more.
Flex Designation:
On-Site DesignatedFlex Eligibility Status:
In this On-Site designated role you will work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertexs Policy on Flex @ Vertex Program and may be changed at any time.
Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a persons race color sex gender identity or expression age religion national origin ancestry ethnicity disability veteran status genetic information sexual orientation marital status or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager or contact Talent Acquisition at
Required Experience:
Staff IC
Employment Type
Full-Time
