Postdoctoral Fellow PhD Student in Systems Neuroscience
Postdoctoral Fellow PhD Student in Systems Neuroscience
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Job Description
The Laboratory of Cortical Information Processing Vision to Action at NERF invites applications for a Postdoctoral Fellow or PhD Student to work on a new research project funded by the Simons Foundation Autism Research Initiative (SFARI). This collaborative initiative with the labs of Pierre Vanderhaeghen (VIB-KU Leuven) and Franck Polleux (Columbia University) aims to elucidate how human-specific features of brain development influence early cortical circuit function and the pathophysiology of autism spectrum disorders (ASD)
Research Project
Linking human-specific synaptic developmental timing to early cortical circuit function and plasticity in ASD
This project addresses a compelling hypothesis: that disruption in the uniquely human prolonged timeline of synapse development—synaptic neoteny—contributes to ASD. The project will explore how SYNGAP1 haploinsufficiency a major monogenic cause of ASD accelerates synaptic development and disrupts early sensory circuit function. A central goal is to understand how these effects are shaped by human-specific SRGAP2 genes which regulate synaptic timing via SYNGAP1.
To achieve this we will use:
- Xenotransplantation models of human cortical neurons into mouse brain
- In vivo 2-photon Ca imaging visual plasticity paradigms and behavioral analysis
- Transgenic mouse models combining SYNGAP1 mutations with humanized SRGAP2C expression
This interdisciplinary work will shed light on the developmental origins of circuit dysfunction in ASD and inform the timing of potential therapeutic interventions.
About the Labs
The Bonin Lab led by Dr. Vincent Bonin (Associate Professor KU Leuven; Principal Investigator VIB) investigates the physiological basis of sensory behavior and brain circuit organization. The lab focuses on how visual information is processed in the brain to guide perception and behavior. Their multidisciplinary team combines in vivo physiology circuit tracing imaging and behavior.
The Vanderhaeghen Lab led by Dr. Pierre Vanderhaeghen (Professor at KU Leuven; Principal Investigator at VIB) investigates the development and evolution of the human brain with a focus on human-specific genetic programs synaptic neoteny and neurodevelopmental disorders.
The labs are located at NERF and VIB-KU Leuven Center for Brain & Disease Research is part of the VIB Life Sciences Institute and is embedded within KU Leuven one of the worlds top 50 universities offering a dynamic and collaborative research environment.
More information:
Candidate Profile
We are seeking a highly motivated and creative neuroscientist with a strong interest in neural development synaptic plasticity and neurodevelopmental disorders.
Required Qualifications:
- PhD (or MSc for PhD applicants) in Neuroscience Neurobiology or related field
- Experience with in vivo imaging electrophysiology optogenetics or behavioral assays
- Strong data analysis skills (Python MATLAB)
Preferred Qualifications:
- Experience with stem cellderived neurons or xenotransplantation
- Interest in cortical circuit plasticity or ASD models
- Background in sensory processing or visual behavior
Outstanding Masters students interested in pursuing a PhD are also encouraged to apply.
What We Offer
- A vibrant collaborative and internationally recognized research environment
- Access to state-of-the-art facilities: 2-photon/3-photon imaging Neuropixels optogenetics behavioral setups
- Competitive salary and benefits
- Guaranteed funding for at least 2 years with encouragement to pursue fellowships (e.g. Marie-Curie EMBO FWO)
- Integration into a dynamic scientific community across NERF VIB and KU Leuven
Application Process
For more information please contact Vincent Bonin:
Please complete the online application procedure.
Please submit:
- CV (including full publication list and preprints)
- Motivation letter and brief research statement
- Contact information for 23 references
Deadline
Applications will be reviewed on a rolling basis until the position is filled.
Connect with us:
- LinkedIn:
Neuro-Electronics Research Flanders (NERF)
VIB-KU Leuven Center for Brain & Disease Research
Discover our lab and centers:
- Bonin Lab:
- NERF:
- VIB-KU Leuven Center for Brain & Disease Research:
- :
- Explore our virtual tour
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Employment Type
Full Time
