Principal Scientist, DMPK
Principal Scientist, DMPK
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$ 213750 - 236250
1 Vacancy
Job Description
Cytokinetics is a late-stage specialty cardiovascular biopharmaceutical company focused on discovering developing and commercializing first-in-class muscle activators and next-in-class muscle inhibitors as potential treatments for debilitating diseases in which cardiac muscle performance is compromised. As a leader in muscle biology and the mechanics of muscle performance the company is developing small molecule drug candidates specifically engineered to impact myocardial muscle function and contractility.
At Cytokinetics each team member plays an integral part in advancing our mission to improve the lives of patients. We are seeking tenacious compassionate and collaborative individuals who are driven to make a positive impact.
Responsibilities
Lead the design execution and interpretation ofbioanalytical (BA) and pharmacokinetic (PK) studiesto support preclinical and clinical development.
Hand-on and overseemethod development validation and sample analysisfor small molecules and/or novel modalities (e.g. siRNA PROTAC) usingSciex LC-MS/MS Orbitrap or Q-TOF machines
Performnon-compartmental (NCA) and compartmental PK analysis PK/PD modeling and translational pharmacokinetics to guide compound optimization and dosing strategies.
Author and reviewtechnical reports regulatory submissions (INDs NDAs BLAs) and scientific publications.
Collaborate closely withtoxicology clinical pharmacology CMC and discovery teamsto ensure suitable study design and robust PK/PD understanding of drug candidates.
Leveraging specialized ADME/PK skills such as in vitro ADME in vivo ADME biotransformation PK/PD or physiologically-based pharmacokinetic modeling (PBPK) to impact project progression and decision-making
Manage externalCROsfor bioanalytical and PK studies ensuring data quality and regulatory compliance (GLP/GCP).
Mentor junior scientists and contribute to departmental initiatives to enhance scientific and operational excellence.
Capable of independently troubleshooting and resolving Sciex LC-MS/MS challenges as they arise in the lab.
Qualifications & Experience:
PhD in Pharmacology Pharmaceutical Sciences Chemistry or related field.
8 yearsof relevant experience inbioanalytical sciences and pharmacokineticswithin the pharmaceutical/biotech industry.
Deep expertise inLC-MS/MS Orbitrap Q-TOF and HPLC methods.
Strong background inPK modeling (WinNonlin Phoenix NONMEM R etc.)and interpretation of PK/PD data.
Experience withregulatory submissions (FDA/EMA/ICH guidelines)and working in a GLP/GCP environment.
Proven leadership skills with the ability to influence cross-functional teams and mentor junior scientists.
Excellent communication problem-solving and project management abilities.
Familiarity withDMPK principles (metabolism transporters drug-drug interactions).
Knowledge ofautomation and high-throughput bioanalytical techniques.
Pay Range:
In the U.S. the hiring pay range for fully qualified candidates is $213750-$236250 per year. The base pay actually offered will take into account internal equity and also may vary depending on the candidates geographic region job-related knowledge skills and experience among other factors.Our employees come from different backgrounds and we celebrate those differences. We are looking for the best candidates for our open roles but do not expect applicants to meet every qualification in order to be considered. If you are excited about what you could accomplish at Cytokinetics and believe you can add value to our team we would love to hear from you.
Please review ourGeneral Data Protection Regulation (GDPR) policyPRIOR to applying.
Our passion is anchored in robust scientific thinking grounded in integrity and critical thinking. We keep the patient front and center in all we do all actions and decisions are in service of the patient and their caregivers. We champion integrity ethics doing the right thing and being our best selves.
Fraud Warning: How to Identify Impersonated Cytokinetics Job Postings and Offers
Recently there have been fraudulent employment offers being sent to candidates on behalf of Cytokinetics. Please be advised that all legitimate offers from Cytokinetics will come directly from our official email domain () and will only be made after completing a formal interview process.
Here are some ways to check for authenticity:
We do not conduct job interviews through non-standard text messaging applications
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If you are unsure about the authenticity of an offer or if you receive any suspicious communication please contact us directly at
Cytokinetics is an Equal Opportunity Employer
Required Experience:
Staff IC
Employment Type
Full-Time
