Proteomics Research Scientist
Proteomics Research Scientist
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Job Description
Job Description
Responsibilities
- Develop optimize and implement targeted proteomics analysis workflows including automated enrichment strategies for precise accurate and sensitive protein measurements using stable isotope dilution and label-free mass spectrometry
- Coordinate with project teams to identify targeted proteomics assay requirements timing samples and deliverables
- Perform targeted protein MS assays using state-of-the-art LC-MS systems; including nano-LC Orbitrap MS platforms to determine protein concentrations in cells or tissues
- Prepare samples from a wide variety of biological matrices (cultured cells tissues plasma biofluids) from human and preclinical species using manual and automated bead-based workflows
- Perform data analysis utilizing a range of proteomics software (Skyline MaxQuant DIANN Spectronaut)
- Maintain and qualify HPLC and MS instrument performance
Qualifications
- PhD in Biochemistry Biology Chemistry Chemical Biology with minimally 2 years of experience in targeted mass spectrometry-based proteomics in industry or startup biotech setting or MS with 5 years of experience
- Broad experience in targeted MS is required
- Hands on experiences on targeted MS method development and execution including highly multiplexed and sensitive PRM stable isotope labeled peptide assays using DDA and DIA data
- Hands on experiences in operating maintaining and troubleshooting nanoLC and Orbitrap MS instruments
- Hands-on experience in sample preparation method development and optimization from various matrices (cells tissues plasma biofluids)
- Demonstrated ability to independently analyze and interpret targeted proteomics data and communicate effectively in a fast paced team-oriented environment
- Experiences in expression proteomics and chemoproteomics are highly desirable
- Demonstrated ability to develop methods and lead mechanism of action mass spectrometry studies
- Develop and optimize mass spectrometry screening assays based on project needs
- Experience with sample preparation from primary cells is a plus
- Motivated problem solver with attention to details great organization skills and time management and ability to multitask efficiently to meet drug discovery timelines team player
Pay Range
$60-$70/HR
Requisition Disclaimer
This job posting is for a temporary role with a third-party agency partner on assignment at Vertex Pharmaceuticals (Vertex). The individual selected for this role will be offered the role as an employee of a third- party agency partner; compensation medical benefits fringe benefits and other terms and conditions of employment shall be presented by the third-party agency partner upon offer. The pay rate range provided is a reasonable estimate of the anticipated compensation range for this job at the time of posting. The actual pay rate will be based on a number of factors including skills competencies experience location and/or being pursued and other job-related factors permitted by law. In addition this role will be eligible for overtime pay in accordance with federal and state requirements
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No C2C or Third-Party Vendors
Employment Type
Unclear
