Laboratory Sciences Principal Professional
Laboratory Sciences Principal Professional
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Job Description
University of Colorado Anschutz Medical Campus
Department:Gates Institute
Job Title: Laboratory Sciences Principal Professional
Position #:Requisition #:37176
Job Summary:
A Laboratory Sciences Principal Professional position is available to assist the Principal Investigators (PI) on multiple projects and oversee general laboratory operations and mouse colony at the Gates Institute. We are looking for a candidate to join our team who is proficient in the field of cellular reprogramming and stem cell differentiation and who is passionate about translational research developing therapies and diagnostic tools for rare conditions. Our research focuses on a variety of projects related to regenerative medicine cellular aging and stem cell therapy development. Among the projects the department develops an induced pluripotent stem cell-based models for studying Ehlers Danlos Syndrome and testing therapies for this condition and other conditions affecting the skin and connective tissues.
The team works closely with the Gates Biomanufacturing Facility (GBF) in advancing cell therapies developed by the laboratory into clinical manufacturing. In the laboratory the department utilizes induced pluripotent stem cells (iPSCs) CRISPR/Cas9 mouse xenograft models human cell culture techniques organoids and other cell and molecular biology techniques. The successful candidate will perform molecular and cellular biology experiments such as immunohistochemical staining western blotting molecular cloning cell culture qPCR ddPCR differentiation of pluripotent stem cells into a variety of cell types and CRISPR-Cas-mediated gene targeting. Laboratory duties will involve receiving laboratory reagents and making stock solutions. The candidate will also oversee the mouse colony and perform animal survival surgeries. This position requires independent judgment in daily operations and in solving non-routine problems. Development of new techniques and independence will be expected and encouraged. The laboratory environment is team-oriented where creativity enthusiasm and dedication are rewarded. In addition the candidate is expected to assist the Stem Cell Biobank and Disease Modeling Core in performing services related to cell reprogramming and gene editing as needed. Furthermore as the Principal Professional the candidate will serve as a subject matter expert (SME) in cellular reprogramming and iPSC differentiation leveraging their expertise to educate and train Core users and collaborators. The candidate will act as a consultative resource providing guidance on experimental design optimization strategies and data interpretation related to cellular reprogramming iPSC differentiation and associated methodologies.
Key Responsibilities:
- Order supplies for daily operations of the laboratory and core using CU Marketplace and purchasing system.
- Prepare lab for daily operations including stocking materials equipment safety cleanliness and related areas.
- Manage procurement and cost analysis.
- Write animal IRB and biosafety protocols.
- Work with a mouse colony and perform mouse survival surgeries
- Oversee independent research projects and plan the scope of work for timely project fulfillment.
- Support the analytical testing process using standard lab support knowledge in the collection and review of conditions including preserving samples completing sample preparation documenting and communicating results.
- Development of new techniques and independence will be expected and encouraged.
- Provide laboratory science expertise and leadership in study design study oversight data management data analysis and manuscript preparation to assist all levels of investigators researchers and clinicians on new research activities across a wide range of disciplines.
- Act as a Subject Matter Expert in the area of cellular reprogramming and iPSC differentiation providing guidance on experimental design optimization strategies and data interpretation related to these methodologies.
Work Location:
Onsite this role is expected to work onsite and is located in Aurora CO
Why Join Us:
The opportunity offered by the Gates Institute is one of a kind. We blend the best of a large research organization of over 40000 employees strong with the family atmosphere of working with a team of 50 highly dedicated people operating on a top tier research campus the University of Colorado Anschutz Medical Campus.
The Gates Institute and its partners on the CU Anschutz Medical Campus are delivering lifesaving therapies and working to develop more every day. We are only limited by our resources and need you to make our journey a success!
In addition to the benefits offered a few links are included below identifying some of the exciting life sciences the Gates Institute isdelivering to patients.
The University of Colorado offers a comprehensive benefits package that includes health insurance life insurance retirement plans tuition benefits ECO pass paid time off vacation sick and holidays and more. To see what benefits are available please visit: work for the University
We haveAMAZINGbenefits and offerexceptional amounts of holiday vacation and sick leave! The University of Colorado offers an excellent benefits package including:
- Medical: Multiple plan options
- Dental: Multiple plan options
- Additional Insurance: Disability Life Vision
- Retirement 401(a) Plan: Employer contributes 10% of your gross pay
- Paid Time Off: Accruals over the year
- Vacation Days: 22/year (maximum accrual 352 hours)
- Sick Days: 15/year (unlimited maximum accrual)
- Holiday Days: 10/year
- Tuition Benefit: Employees have access to this benefit on all CU campuses
- ECO Pass: Reduced rate RTD Bus and light rail service
There are many additional perks & programs with the CU Advantage.
Qualifications:
Minimum Qualifications:
- A bachelors degree in biology molecular biology chemistry genetics or a directly related field from an accredited institution.
- Substitution: A combination of education and related technical/paraprofessional experience may be substituted for the bachelors degree on a year for year basis.
- Substitution: A combination of education and related technical/paraprofessional experience may be substituted for the bachelors degree on a year for year basis.
- Four (4) years of professional-level research experience including three (3) years of extensive hands-on experience in iPSC generation maintenance and differentiation.
- Experience working with primary human cells and molecular biology techniques.
- Experience working with animal models
Condition of Employment: Must be willing and able
- Work with human cell lines and tissues and bodily fluids.
- Work with animal models (mice).
Preferred Qualifications:
- Five (5) years of experience in an experimental or wet laboratory.
- Experience working with mammalian cell cultures.
- Experience working with human primary cell lines.
- Four (4) years of extensive experience with iPSC generation maintenance and differentiation.
- Publications in the iPSC field.
- Experience working with laboratory animals.
- Experience with molecular biology and biochemical techniques.
- Experience in training and mentoring others in a laboratory setting.
- Experience working and managing a core facility
Competencies: Knowledge Skills and Abilities:
- Able to design and execute controlled experiments independently.
- Ability to communicate effectively both in writing and orally.
- Ability to establish and maintain effective working relationships with employees at all levels throughout the institution.
- Outstanding customer service skills.
- Good organizational skills.
- Proficient in the English language.
- Strong work ethic.
- Excellent record keeping abilities.
- Willingness to learn.
- Possess independent judgement in daily operations and in solving non-routine problems as well as fiduciary responsibility.
How to Apply:
For full consideration please submit the following document(s):
1. A letter of interest describing relevant job experiences as they relate to listed job qualifications and interest in the position
2. Curriculum vitae / Resume
3. Three to five professional references including name address phone number (mobile number if appropriate) and email address
Screening of Applications Begins:
Immediately and continues until June 30th 2025.
Anticipated Pay Range:
The starting salary range (or hiring range) for this position has been established as: $62606 - $79635
The above salary range (or hiring range) represents the Universitys good faith and reasonable estimate of the range of possible compensation at the time of posting. This position may be eligible for overtime compensation depending on the level.
Your total compensation goes beyond the number on your paycheck. The University of Colorado provides generous leave health plans and retirement contributions that add to your bottom line.
Total Compensation Calculator: Employment Opportunity Statement:
CU is an Equal Opportunity Employer and complies with all applicable federal state and local laws governing nondiscrimination in employment. We are committed to creating a workplace where all individuals are treated with respect and dignity and we encourage individuals from all backgrounds to apply including protected veterans and individuals with disabilities.
ADA Statement:
The University will provide reasonable accommodations to applicants with disabilities throughout the employment application process. To request an accommodation pursuant to the Americans with Disabilities Act please contact the Human Resources ADA Coordinator at .
Background Check Statement:
The University of Colorado Anschutz Medical Campus is dedicated to ensuring a safe and secure environment for our faculty staff students and visitors. To assist in achieving that goal we conduct background investigations for all prospective employees.
Vaccination Statement:
CU Anschutz strongly encourages vaccination against the COVID-19 virus and othervaccine preventable diseases. If you work visit or volunteer in healthcare facilities or clinics operated by our affiliated hospital or clinical partners or by CU Anschutz you will be required to comply with the vaccination and medical surveillance policies of the facilities or clinics where you work visit or volunteer respectively. In addition if you work in certain research areas or perform certain safety sensitive job duties you must enroll in theoccupational health medical surveillance program.
Required Experience:
Staff IC
Employment Type
Full-Time
