Principal Scientist I/II, Viral Vector Engineering
Principal Scientist I/II, Viral Vector Engineering
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$ 114100 - 211900
1 Vacancy
Job Description
Band
Level 4Job Description Summary
Position is onsite in San Diego CAInternal Title: Principal Scientist I/II
This is a dual posting. The final level & title of the offer role would be determined by the hiring team based on the skills experience & capabilities required to perform the role at the level the role has been offered
The Biologics Research Center (BRC) is accommodated within the Biomedical Research (BR). BRC in collaboration with the disease areas (DA) and technical expert groups builds the future biologics therapy pipeline of Novartis through the discovery and creation of new antibody protein nucleic acid and virus-based molecules.
We are currently recruiting a highly motivated Principal Scientist I/II with strong expertise in AAV-based gene therapy molecular biology and drug discovery. The ideal candidate will have experience with AAV biology and a track record of advancing drug discovery programs through preclinical development in a biotech or pharmaceutical industry setting. This individual will be responsible for evolving novel capsid variants for effective transduction of desired tissues/cell types and will collaborate with other functions within a highly matrixed organization with the goal of delivering our genetic medicines pipeline.
Job Description
Key Responsibilities:
- Conceive design and execute in vitro and in vivo directed evolution campaigns for developing engineered tissue-tropic AAV capsid variants
- Perform bioanalysis for in vitro and in vivo studies to validate lead candidate capsids
- Establish in vitro model systems including stable cell lines iPSC-derived cells and primary cells and develop assays needed to identify mechanisms of action of evolved capsid variants
- Manage research associates to execute experiments in alignment with project timelines. Review data and document experiments in SOPs study reports and ELN entries.
- Collaborate with cross-functional teams including researchers bioinformaticians translational scientists and regulatory affairs colleagues to design and execute studies.
- Stay up-to-date with the latest advancements in the AAV gene therapy field.
This is a dual posting. The final level & title of the offer role would be determined by the hiring team based on the skills experience & capabilities required to perform the role at the level the role has been offered
Essential Requirements:
- PhD degree with 4 years industry experience in molecular biology genomics neuroscience or related fields.
- Experience with high-throughput Next Generation Sequencing (NGS)-based screens and library preparation workflows.
- Proficiency in molecular biology techniques including cloning and DNA/RNA/protein quantification methods (such as qPCR ddPCR western blotting ELISA).
- Proficiency with mammalian cell culture.
- Strong organization communication and project management skills. Comfortable working in a fast-paced collaborative environment. Able to efficiently coordinate among project teams particularly with respect to resource needs and timelines.
- Able to work independently troubleshoot technical issues and contribute subject matter expertise to project teams. Able to present results and propose strategies to senior management and external partners.
Desirable Requirements:
- Experience with iPSC-derived and primary cells immunofluorescent staining and imaging and/or FACS is preferred.
- Track record of leading discovery stage programs through preclinical development in an industry setting. Experience with AAV-based gene therapy is preferred.
- Experience managing direct reports is preferred.
Novartis Compensation and Benefit Summary: The salary for this position is expected to be:
- Principal Scientist I $103600 and $192400 per year
- Principal Scientist II $114100 and $211900 per year
The final salary offered is determined based on factors like but not limited to relevant skills and experience and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors.
Your compensation will include a performance-based cash incentive and depending on the level of the role eligibility to be considered for annual equity awards.
US-based eligible employees will receive a comprehensive benefits package that includes health life and disability benefits a 401(k) with company contribution and match and a variety of other benefits. In addition employees are eligible for a generous time off package including vacation personal days holidays and other leaves.
EEO Statement:
The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment hiring training promotion or other employment practices for reasons of race color religion gender national origin age sexual orientation gender identity or expression marital or veteran status disability or any other legally protected status. We strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.
Accessibility and reasonable accommodations
The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If because of a medical condition or disability you need a reasonable accommodation for any part of the application process or in order to perform the essential functions of a position please send an e-mail to call 1 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
Range
Skills Desired
Analytical Skill Analytical Skill Analytical Thinking Chemical Biology Chemistry Clinical Trials Collaboration Communication Skills Curiosity Data Data Analysis Design Of Experiments Detail-Oriented Drug Development Drug Discovery Ethics Gene Therapy Immunology Inventory Management Laboratory Lifesciences Machine Learning (Ml) Management Medical Research Molecular Biology 10 moreRequired Experience:
Staff IC
Employment Type
Full-Time
