Associate Principal Scientist: Molecular Modeling, Analytical Research & Development
Associate Principal Scientist: Molecular Modeling, Analytical Research & Development
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$ 139600 - 219700
1 Vacancy
Job Description
Job Description
Associate Principal Scientist: Molecular Modeling Analytical Research & Development
Our Scientists are our Inventors. We deliver robust scientific data and interpretation that drives the commercialization of breakthrough therapeutics using innovative thinking state-of-the-art facilities and modern equipment. Our ability to excel depends on the integrity knowledge imagination skill diversity and teamwork of people like you. To this end we strive to create an environment of mutual respect encouragement and teamwork. As part of our global team youll have the opportunity to collaborate with talented and dedicated colleagues while developing your career.
The Analytical Research & Development organization in Rahway NJ Boston MA or West Point PA is seeking a motivated Associate Principal Scientist with technical expertise in atomistic modeling of drug substance and drug formulations with an ability to apply predictive sciences to support pipeline of antibodies small molecules peptides biologics conjugates and vaccines. This role will allow the candidate to solve complex scientific challenges through application of data modeling analysis and visualization tools. Initial focus will be related to modeling of antibodies and small molecule drug formulations. The successful candidate is expected to collaboratively work with synthetic formulation computational and analytical scientists understand their problem statements and collaboratively implement and apply predictive science solutions. The candidate must be able to work proactively and independently and influence decisions and solutions spanning a wide diversity of problem statements across Research Laboratories. The role will require the candidate to network across a range of departments and effectively collaborate with stakeholders. The candidate should exemplify positive ways of working which support diversity inclusion and a positive culture. The chosen candidate should have a demonstrated ability to publish and present research including an established track record of interaction with the broader scientific community.
Establishing data workflows data visualizations and predictive tools to enable more effective identification characterization and development of novel medicines and vaccines is a key objective for our company. This position sits within the Digital Sciences team in the Analytical Enabling Capabilities sub-department of Analytical Research & Development. You will be part of a team working collaboratively across a wide range of areas impacting all aspects of the drug discovery and development pipeline. A diverse array of projects spanning data curation to data analysis to predictive sciences will be encountered in this role. The core Digital Sciences team works with a networked group of digital champions across AR&D and has close connectivity to other digital facing teams across Research Laboratories including critical IT collaborators.
Primary Responsibilities
Expert execution of atomistic molecular modeling and molecular dynamics simulations
Helping to coordinate best practices in atomistic modeling across departments
Application of predictive approaches to address scientific problems across analytical characterization techniques
Application of data science workflows to address pipeline challenges across all modalities
Application and generation of data analysis and visualization workflows
Input on development of dashboards reports and data exports
Influence definition of digital strategy
Meet with collaborators to collect requirements
Manage projects and timelines
Presentation of updates to collaborators
Education Requirements
A Ph.D. in Computational Chemistry Chemistry Biochemistry Engineering Data Science Mathematics Physics Biology Pharmaceutical Sciences or a closely-related field with at least 4 years of relevant experience
A M.S. in Computational Chemistry Chemistry Biochemistry Engineering Data Science Mathematics Physics Biology Pharmaceutical Sciences or a closely-related field with at least 6 years of relevant experience
A B.S. in Computational Chemistry Chemistry Biochemistry Engineering Data Science Mathematics Physics Biology Pharmaceutical Sciences or a closely-related field with at least 8 years of relevant experience
Required Experience and Skills
Expertise in atomistic modeling (direct experience with antibodies and at least one other modality: small molecules peptides biologics conjugates and vaccines)
Expertise in executing molecular dynamics simulations of multi-component systems
Expertise across multiple computational modeling platforms such as: Maestro MOE OpenEye Gaussian ORCA etc.
Familiar with programming in R and/or Python and Posit/RStudio/Jupyter
Experience with one or more data visualization tools (Shiny Spotfire Dash PowerBI Streamlit or Tableau)
Excellent verbal and written communications skills
Work independently and be able to collaborate as a team
Strive for continuous improvement and suggest innovative solutions to scientists common challenges
Insatiable curiosity to learn with the end goal of understanding the scientific problem statement and designing programs software or solutions to meet the end users needs
Preferred Experience and Skills
Multi-scale modeling including coarse grained molecular dynamics
Machine learning
Experience with pharmaceutical drug product development involving formulation design
Knowledge of development of chemical matter across one or more modalities
Track record of impact in the pharmaceutical industry with relevant examples directed towards pipeline objectives
Development of dashboards reports and data exports
Scientific supervisory experience related to guiding the work of junior scientists.
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U.S. Hybrid Work Model
Effective September 5 2023 employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week Monday - Thursday although the specific days may vary by site or organization with Friday designated as a remote-working day unless business critical tasks require an on-site Hybrid work model does not apply to and daily in-person attendance is required for field-based positions; facility-based manufacturing-based or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note this Hybrid work model guidance also does not apply to roles that have been designated as remote.
The salary range for this role is
$139600.00 - $219700.00This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employees position within the salary range will be based on several factors including but not limited to relevant education qualifications certifications experience skills geographic location government requirements and business or organizational needs.
The successful candidate will be eligible for annual bonus and long-term incentive if applicable.
We offer a comprehensive package of benefits. Available benefits include medical dental vision healthcare and other insurance benefits (for employee and family) retirement benefits including 401(k) paid holidays vacation and compassionate and sick days. More information about benefits is available at can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.
San Francisco Residents Only:We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only:We will consider for employment all qualified applicants including those with criminal histories in a manner consistent with the requirements of applicable state and local laws including the City of Los Angeles Fair Chance Initiative for Hiring Ordinance
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Merck & Co. Inc. Rahway NJ USA also known as Merck Sharp & Dohme LLC Rahway NJ USA does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place introductions are position specific. Please no phone calls or emails.
Employee Status:
RegularRelocation:
VISA Sponsorship:
Travel Requirements:
Flexible Work Arrangements:
HybridShift:
Valid Driving License:
Hazardous Material(s):
Required Skills:
Adaptability Adaptability Analytical Method Development Applied Engineering Assay Development Biochemistry Biological Assay Development Biopharmaceuticals Business Cell-Based Assays Chromatographic Techniques Computational Chemistry Cross-Functional Teamwork Data Modeling Data Science Drug Discovery Process External Collaboration High Resolution Mass Spectrometry (HRMS) Immunochemistry Liquid Chromatography-Mass Spectrometry (LC-MS) Management Process Mass Spectrometry Analysis Molecular Modeling Multidisciplinary Collaboration Optimistic Attitude 5 morePreferred Skills:
Job Posting End Date:
07/7/2025*A job posting is effective until 11:59:59PM on the day BEFOREthe listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
Required Experience:
Staff IC
Employment Type
Full-Time
