Principal Oligonucleotide Scientist
Principal Oligonucleotide Scientist
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Not Disclosed
Salary Not Disclosed
1 Vacancy
Job Description
- Function as an MS subject matter expert within Analytical Development and be viewed as peer to other MS SMEs within Eurofins network
- Perform method development feasibility qualification and/or validation of methods in support of biopharmaceutical products using primarily Mass spectrometry
- Execute identification of unknown compounds with minimal support
- Develop and execute validation plans
- Troubleshoot method and instrumentation problems
- Generate complete accurate and concise documentation using electronic systems and laboratory notebook
- Author documents (e.g. development reports methods and client reports)
- Give presentations for training and client reviews
- Have a strong understanding of current regulatory expectation
- Effectively guide more junior scientists on technical issues
- Use office and instrumentation specific computer software
- Contribute to set up an oligonucleotide testing laboratory and establish processes workflows and general operations
- Developing and validating new QC methods to assess the suitability stability and functionality of a range of oligonucleotides through a variety of analytical and functional tests
- HPLC and high resolution mass spectrometry method development for oligonucleotide characterization
- Installation and verification of equipment documenting processes and training operators
- Support various analytical instrument operation maintenance and troubleshooting to sustain analytical performance data reproducibility and reliability to deliver results to project teams within a timely manner
- Champion and implement new and innovative analytical applications and technology
- Advise clients on analytical scope to meet technical and regulatory requirements
- Handling any customer related queries where necessary and liaising with the team to problem solve these queries if needed
- Provide training/mentoring to junior staff
Qualifications :
- B.S. / M.S. degree in Chemistry Biology biochemistry or related technical discipline with 4 years of relevant experience either post-doctoral or in the bio/pharmaceutical industry
- Hands-on experience in use of multiple types of mass spectrometers (GC/MS LC/MS HRMS)
- Experience with identification of unknown materials
- Ability to work independently and as part of a team with internal and external clients selfmotivation adaptability and a positive attitude.
- Strong organizational and time management skills
- Excellent communication (oral and written) and attention to detail
- Ability to learn new techniques perform multiple tasks simultaneously keep accurate records follow instructions and comply with company policies
- Authorization to work in the United States indefinitely without restriction or sponsorship.
- Extensive knowledge of oligonucleotide based drug products including ASO siRNA mRNA
- Subject matter expert analytical chemistry knowledge including theory and application of three or more chromatographic and spectroscopic techniques for identification purity and assay of various analytes
- Operate and troubleshoot available instruments including HPLC and MS
- Experience with an assortment of different HPLC separations which includes IEX RP SEC etc.
- Hands-on experience in QC of oligonucleotides
Additional Information :
Position is full-time position Monday - Friday 8:00am - 4:00pm. Candidates currently living within a commutable distance of Lancaster PA are encouraged to apply.
- Excellent full time benefits including comprehensive medical coverage dental and vision options
- Life and disability insurance
- 401(k) with company match
- Paid vacation and holidays
To learn more about Eurofins please explore our website .
Eurofins USA BioPharma Services is a Disabled and Veteran Equal Employment Opportunity employer.
Remote Work :
No
Employment Type :
Full-time
Employment Type
Full-time
