Postdoctoral Fellow - Lee Lab
Postdoctoral Fellow - Lee Lab
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Job Description
Salary for this Role:
From 45500 with benefits subject to skills and experience.
Job Title:
Postdoctoral Fellow - Lee LabReports to:
James Lee CClosing Date:
23.59 GMTJob Description:
Job title: Postdoctoral Fellow (Genetic Mechanisms of Disease Lab)
Details of the role: 4 yr FTC full-time. Working pattern: Monday Friday.
Salary: From 45500 pa with benefits subject to skills and experience
Application closing date: No closing date 23:59 GMT
About us
The Francis Crick Institute is Europes largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent diagnose and treat illnesses such as cancer heart disease infectious diseases and neurodegenerative conditions.
The Crick is a place for collaboration innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure cutting-edge facilities and a creative and curious culture. Weve removed traditional boundaries of departments divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.
About the role
The Genetic Mechanisms of Disease lab is a dynamic supportive and highly collaborative research group which studies how common genetic variation influences the human immune system and how this can predispose to autoimmune and inflammatory disease. A strong background in human immune cell isolation and culture CRISPR editing and in vitro assays of immune function are essential.
The current project which is funded via the MSD/Crick Research Alliance aims to elucidate the biology responsible for a genetic association with inflammatory bowel disease (IBD) which is located on chromosome 5. The associated locus lies within an uncharacterised long non-coding (lnc)RNA and exhibits strong activation-dependent enhancer activity in inflammatory macrophages. The aims of the project are to identify the gene(s) that may be regulated by this dynamic enhancer investigate whether the lncRNA has RNA-dependent functions and characterise the molecular and cellular mechanisms by which this genetic variation contributes to IBD. Our goal is to not only resolve molecular and cellular mechanisms of disease but to identify new opportunities for therapy.
For an example of the sort of research we conduct please see Stankey Bourges Haag et al. Nature 2024
What you will be doing
As a Postdoctoral Fellow at the Crick you will:
Lead your own research projects
Contribute to other research projects both internally and with external collaborators
Guide PhD students in their research
About you
The essential criteria you will bring
PhD or in the final stages of PhD completion in a relevant biomedical science (including but not limited to: immunology molecular biology cell biology biochemistry)
Experience in molecular biology mammalian cell culture and flow cytometry
Knowledge of human genetics immunology and gene regulation.
Experience of working independently designing experiments and adopting new techniques
Track record of scientific writing evidenced by first author publications or submitted manuscripts in refereed journals
Ability to work independently and as part of a small team
Excellent organisational and communication skills
To see the complete job description click here.
To learn more about team/Group Leader click here.
About Working at the Crick
Our values
Everyone who works at the Crick has a valuable role to play in advancing the Cricks mission and shaping our culture!
We arebold. We make space for creative dynamic and imaginative ideas and approaches. Were not afraid to do things differently.
We areopen. Were highly collaborative and interactive and make sure our activities are visible to the outside world.
We arecollegial. We show respect for one another work cooperatively and support the wider community.
At the Francis Crick Institute we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued respected and empowered to succeed regardless of their background identity or personal circumstances. We actively encourage applications from individuals of all genders ethnicities abilities and experiences. We are a Disability Confident: Committed employer and you will be asked as part of the process if you wish to apply under the scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e. would like to apply by phone or post)please email:
To find out more about life at the Crick click here.
What will you receive
At the Francis Crick Institute we value our team members and are proud to offer an extensive range of benefits to support their well-being and development:
Visas: Applicants for this role will be eligible for sponsorship to work in the UK
Generous Leave: 28 days of annual leave plus three additional days over Christmas and bank holidays.
Pension Scheme: Defined contribution pension with employer contributions of up to 16%.
Health & Well-being:
24/7 GP consultation services.
Occupational health services and mental health support programs.
Eye care vouchers and discounted healthcare plans.
Work-Life Balance:
Back-up care for dependents.
Childcare support allowance.
Annual leave purchase options.
Crick Networks offering diverse groups support community and inclusive social events.
Perks:
Discounted gym memberships bike-to-work scheme and shopping discounts.
Subsidised on-site restaurant and social spaces for team interaction.
Development & Recognition: Comprehensive training mentoring and a pay structure based on skills and experience.
Employment Type
Full-Time
