Senior Scientist I, Protein Analytics, Biologics Discovery Sciences
Senior Scientist I, Protein Analytics, Biologics Discovery Sciences
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1 Vacancy
Job Description
We are seeking a highly motivated Senior Scientist I with a diverse protein biochemistry background to join our Protein Analytics team within our Biotherapeutic Discovery Production group. The team is responsible for characterizing purity and key product quality attributes of candidate molecules to advance those with the greatest probability of success as well as guiding protein engineering and production path development activities.
The successful candidate will be focused on implementing and conducting various assays to monitor process impurities and to assess the function of Biotherapeutics with the aim of fully characterizing lead/candidate molecules and identifying potential molecular liabilities. Some of the techniques/methods utilized in the position include 1) released glycan assay (RGA) using BioAccord LC-MS system; 2) surface plasmon resonance (SPR) using Biacore for assessment of antigen binding and binding of antibody Fc receptors; and 3) isoelectric focusing (IEF) and capillary electrophoresis (CE). The role also includes assessment of thermal/chemical stability to extend understanding of potential liabilities and inform engineering efforts and candidate selection. The position will be responsible for developing and implementing new technologies/platforms that improve the efficiency of the overall drug-discovery process for multispecific therapeutic proteins as well as data tracking and reporting and will require collaboration with the production group and other analytics teams.
Key Responsibilities:
- Implement and conduct assays to monitor process impurities and to assess the function of Biotherapeutics such as RGA SPR IEF CE-SDS etc.
- Identify develop and implement new technologies/platforms that improve the efficiency of the overall drug-discovery process for multispecific therapeutic proteins.
- Maintain a high level of productivity in the lab conducting research independently and managing several projects simultaneously. Independently design execute and interpret experimental results. Caretaking and troubleshooting key instrumentation.
- Optimize workflows to address evolving timelines and priorities by integrating automation into platform methods.
- Contribute to project teams and work effectively across functional groups to help advance programs.
- Stay current with applicable internal/external scientific literature and apply new information in innovative ways to successfully complete work assignments.
- Routinely demonstrate scientific initiative and creativity in research activities.
- Demonstrates high proficiency across a wide range of relevant technologies.
- Analyze document and report data concisely and rigorously.
Qualifications :
- BS MS or Ph.D. in Biochemistry Biophysics Analytical Chemistry or related field with typically 0-4 years (with PhD) 8-10 years (with MS) or 10-12 years (with BS) of experience.
- Demonstrated skill in RGA to characterize glycan profiles of biologic drug candidate molecules is a must.
- Must be proficient in SPR analysis to characterize target binding attributes of novel Biotherapeutics.
- Well versed in other techniques to assess quality attributes of biotherapeutic molecules such as IEF and CE-SDS for example.
- Ability to deliver near real-time analytical results to guide the biotherapeutic candidate production process path is required.
- Demonstrated ability to oversee maintain and troubleshoot lab equipment.
- Should possess excellent communication skills and be proficient in presenting in front of groups.
Additional Information :
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location and we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our short-term incentive programs.
Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of any bonus commission incentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole and absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
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No
Employment Type :
Full-time
Employment Type
Full-time
