Postdoctoral Researcher
Postdoctoral Researcher
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Job Description
Union: Non-Union
Number of Vacancies: 1
Site: Princess Margaret Research Institute
Department: Radiation Oncology
Reports to: Principal Investigator
Work Model: On-Site
Shifts: Monday - Friday
Status: Temporary Full-Time
Hours: 37.5 hours per week
Closing Date: June 30 2025
Position Summary:
We are interested in recruiting a highly dedicated and motivated Postdoctoral Researcher to join the Kwan and Liu Labs at the Princess Margaret Research Institute. We apply molecular biology techniques to research on human biospecimens cell and mice models with side effects of cancer treatment such as radiation fibrosis and lymphedema. The goal is to develop novel personalized approaches for the prevention and treatment of long-term and late effects of cancer treatment. The successful candidate will be co-supervised by both labs and will have the opportunity to contribute to several projects including:
- Investigating the mechanisms of action underlying side effects related to cancer treatment such as radiation fibrosis and lymphedema
- Evaluation of biomarkers of radiation fibrosis and lymphedema
- Development of novel drug therapies for radiation fibrosis and lymphedema
Labs:
Research in the Kwan Lab is focused on the development of novel circulating biomarkers to facilitate early detection and prognostication for breast cancer-related lymphedema. Using molecular biology techniques they also aim to understand the underlying metabolic and inflammatory mechanisms of action in lymphedema to identify novel therapeutic targets.
The Liu Lab is a leader in research on head and neck cancers and radiation fibrosis. They focus on several aspects of translational molecular oncology including the development of biomarkers for head and neck cancers high-throughput screens to identify novel anti-cancer therapeutics and new drug therapies for radiation fibrosis.
Duties:
- Cell culture
- Mice handling (including blood sampling and tissue processing) and microsurgery
- Perform genetic knockout/overexpression experiments of candidate genes in cell and mice models
- Perform drug evaluation in cell and mice models
- Nucleic acid isolation PCR ELISA western blotting
- Collection curation and analysis of genomic/epigenomic data
- Development of integrative modeling approaches for the identification of prognostic molecular predictors
- Write and publish peer-reviewed scientific publications
Professional and Career Development:
In addition to scientific knowledge and skill development the selected applicant will have access to unique educational and networking opportunities. Examples are below:
- Enrolment with the UHN Office of Research Trainees (ORT) for complementary training and professional development
- Access to the UHN Princess Margaret Research Institutes scientific seminars and rounds
- Access to training programs including the Princess Margaret Cancer Centres Biosciences Oncology Leadership Development (BOLD) Program
- Mentorship in manuscript writing and review grant writing and supervision of trainees
- Conference travel
Qualifications :
- Candidates must have at minimum a PhD in Molecular Biology or relevant field of study
- At least 3 years of experience with nucleic acid isolation quantitative real-time PCR ELISAs western blotting immunohistochemistry immunofluorescence cell culture and mouse handling
- Hands-on experience with high performance computing and genomic analysis in R in a cluster environment and analysis of single cell omics data analysis are assets
- Willingness to learn new techniques and technologies (including establishing and optimizing new protocols)
- Excellent competency in written and verbal communications
- Write and publish peer-reviewed scientific publications
- Ability to plan experiments work independently accurately and meet deadlines
Additional Information :
Why join UHN
In addition to working alongside some of the most talented and inspiring healthcare professionals in the world UHN offers a wide range of benefits programs and perks. It is the comprehensiveness of these offerings that makes it a differentiating factor allowing you to find value where it matters most to you now and throughout your career at UHN.
- Competitive offer packages
- Government organization and a member of the Healthcare of Ontario Pension Plan (HOOPP access to Transit and UHN shuttle service
- A flexible work environment
- Opportunities for development and promotions within a large organization
- Additional perks (multiple corporate discounts including: travel restaurants parking phone plans auto insurance discounts on-site gyms etc.)
Current UHN employees must have successfully completed their probationary period have a good employee record along with satisfactory attendance in accordance with UHNs attendance management program to be eligible for consideration.
All applications must be submitted before the posting close date.
UHN uses email to communicate with selected candidates. Please ensure you check your email regularly.
Please be advised that a Criminal Record Check may be required of the successful candidate. Should it be determined that any information provided by a candidate be misleading inaccurate or incorrect UHN reserves the right to discontinue with the consideration of their application.
UHN is an equal opportunity employer committed to an inclusive recruitment process and workplace. Requests for accommodation can be made at any stage of the recruitment process. Applicants need to make their requirements known.
We thank all applicants for their interest however only those selected for further consideration will be contacted.
Remote Work :
No
Employment Type :
Contract
Employment Type
Contract
