Senior Associate Scientist, Cellular Process Development

At KSQ Therapeutics we seek to understand the role of every human gene in each disease each tissue and each cell that we study. This comprehensive approach has resulted in a massive experimentally derived dataset that we have found to be remarkably predictive of past successes and failures in oncology and immunooncology product development. Utilizing this approach we also identified a number of opportunities for the development of new medicines. As a result we have aggressively invested in these distinct highly validated pathways for new drug development with the expectation that the medicines we create may become the next breakthrough products for patients.

Founded in late 2015 KSQ is a clinicalstage biotech that has rapidly advanced the field of CRISPRenabled functional genomics from in vitro cell autonomous screens to more complex genomescale screens of immune cells in vivo. The company has expanded the scope of its technology to include multiple cell types and to unlock areas beyond oncology. KSQ is led by a team of accomplished industry experts in drug discovery and development.

KSQ is led by a team of accomplished industry experts in drug discovery and development. When you join KSQ youre not just landing a new gig. You become part of a team of doers thinkers and collaborators who embrace and live by our values:

• COLLABORATION
• AUTHENTICITY
• RESILIENCE
• EXCELLENCE

Position Summary:

KSQ Therapeutics Inc. is seeking a selfmotivated and dependable Senior Associate Scientist to join our Adoptive Cell Therapy team. Our ideal candidate thrives in a research environment that demands scientific rigor and technical excellence. Applicants with an interest in T cell immunology and expertise in cell culture CRISPRCas9 technology and cell biology are strongly encouraged to apply.

Key responsibilities include the following:

• Contribute to the development of KSQs engineered eTIL (Tumor Infiltrating lymphocytes) cell therapy pipeline including the design and execution of process development activities
• Design and execute cell and molecularbased assays for validation of T cell therapy edits
• Timely documentation of development reports and ELNs
• Develop and deliver scientific presentations and reports in a fast and efficient manner
• Prepare and present technical data and technical reports for internal use and to external partners
• Provide technical support to crossfunctional groups and external collaborators
• Participate in various aspects of small company capability building

Requirements

• B.S. or M.S. in biology immunology or relevant field
• 23 years of experience in a relevant academic or biopharmaceutical setting
• Ability to commute to site location in Lexington MA. Position will be hybrid with approximately 80% onsite (primarily in the lab) 20% remote.
• Proficiency in mammalian cell culture and aseptic cell culture techniques
• Experience in designing performing and interpreting the results of multicolor flow cytometry for phenotyping and functional analysis of immune cells preferred
• Experience with technology transfer to a CDMO preferred
• Handson experience in diverse cell biology techniques (cell isolation proliferation assays T cell expansion cytotoxicity functionality assays and etc.) and molecular biology techniques
• Experience in CRISPR/Cas9 geneediting tools and cloning techniques is a plus
• Demonstrated commitment to quality and great attention to details especially pertaining to review of reports experimental results and raw data.
• Ability to maintain a clean and organized lab space including but not limited to inventory management via a Kanban min/max system and 5S methodology
• Excellent verbal/written communication and presentation skills
• Ability to contribute to multiple parallel projects under demanding timelines
• A record of achievement in research and scientific creativity in the areas of immunology oncology inflammation immunooncology and/or drug discovery
• Must be enthusiastic curious collaborative & openminded
• Must be able to give and receive constructive feedback
• Must have patience integrity and honesty

KSQ Therapeutics is proud to be an Equal Opportunity Employer.

COVID19 vaccination is a condition of employment at KSQ subject to reasonable accommodation where required by law. Employees must be fully vaccinated by date of hire to be considered.