Principal Research Scientist I, Discovery Biotherapeutics - In Vitro Technologies
Principal Research Scientist I, Discovery Biotherapeutics - In Vitro Technologies
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1 Vacancy
Job Description
Discovery Biotherapeutics at AbbVie is seeking a highly motivated Principal Research Scientist to lead a dynamic team supporting biologics drug discovery and engineering. The candidate will leverage expertise to develop and implement research plans for antibody identification/optimization supporting all AbbVies therapeutic areas. The ideal candidate should have extensive experience with in vitro display technologies for therapeutic discovery and engineering a proven track record generating novel synthetic libraries and project leadership to advance early and latestage discovery programs. They should possess excellent communication skills be comfortable presenting in group settings and having experience managing teams of 4 or more scientists. The applicant should be an enthusiastic creative scientist who will make tangible contributions to the continuous improvement and innovation within the organization.
Key Responsibilities:
- Lead a team applying in vitro display technologies for biotherapeutics discovery and engineering to support all AbbVie therapeutic areas
- Implement novel selection strategies and build industryleading libraries for discovery and screening of therapeutic candidates
- Identify and solve technical problems independently conceive and implement innovative research ideas
- Evaluate and integrate stateoftheart technology to improve therapeutic discovery platforms and demonstrate creative outofthebox thinking to solve difficult problems
- Ensure consistency and quality of technical reports from employees supervised
- Lead one or more teams and influence areas in own discipline within department
- Provide project updates analyses and advice to crossfunctional teams and senior management
- Present original work internally across departments and at internal and external scientific conferences; may author or coauthor peerreviewed scientific papers or patents
- Supervise a team of 5 scientists evaluate team performance and is accountable for the effective performance of team
- Act as subject matter expert support and contribute to implementing and improving current workflows
- Ability to engage internal and external scientific leaders in collaborative research
- Serve as a biologics lead for crossfunctional teams and contribute scientific insights into multiple projects across various therapeutic areas; recognized and sought out as an expert in discovery and engineering of therapeutic molecules
Qualifications :
- PhD MS or BS degree in Biochemistry Biochemical engineering or related disciplines with typically 6 (PhD) 12 (MS) or 14 (BS) years of experience in in vitro display technologies and applications to discover and engineer therapeutic proteins
- Sound scientific understanding of current state of in vitro antibody discovery
- Experience leading a team in discovery and/or engineering of diverse protein therapeutic formats
- Deep understanding of antibody structure and function
- Extensive experience and uptodate knowledge in antibody engineering and optimization (e.g. humanization Fc optimization) best practices
- Ability to explore and develop new approaches to further advance innovative in vitro discovery and screening technologies
- Background in biophysical and structural characterization of antibodies fragments and other binding domains
- Extensive experience in design and construction of novel antibody fragment and mimetic libraries
- Experience with bacterial toxin structurefunction stability preferred
- Experience in display of complex proteins nonantibodylike preferred
- Experience with viral antigens and vaccine design preferred
- Excellent organizational skills and the ability to manage multiple projects simultaneously
- Team player with the ability to operate in a fastpaced multidisciplinary environment
- Adapt to rapid changes in project priorities and timelines
- Recognized in the scientific community through a sustained record of peerreviewed publications and patents preferred
- Candidate must be a goaloriented team player with excellent verbal and written communication skills strong cando attitude and experience in leading or managing teams
Key AbbVie Competencies:
- Builds strong relationships with peers and cross functionally with partners outside of the team to enable high performance.
- Learns fast grasps the essence and can change the course quickly where indicated.
- Raises the bar and is never satisfied with the status quo.
- Creates a learning environment open to suggestions and experimentation for improvement.
- Embraces the ideas of others nurtures innovation and manages innovation to reality.
Additional Information :
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location and we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our shortterm incentive programs.
This job is eligible to participate in our longterm incentive programs
Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of any bonus commission incentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole and absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
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No
Employment Type :
Fulltime
Employment Type
Full-time
