Postdoctoral Fellow â High Concentration Protein Formulations, Biopharmaceutical Development
Postdoctoral Fellow â High Concentration Protein Formulations, Biopharmaceutical Development
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Job Description
Postdoctoral Fellow High Concentration Protein Formulations Biopharmaceutical Development
Location: Gaithersburg US
Department: Biopharmaceuticals
Our Postdoc Programme is for selfmotivated individuals looking to take on interesting high impact projects in a collaborative challenging and reputable environment. Do you have expertise in and passion for biophysics analytics and formulation development Would you like to apply your expertise to impact the development of high concentration patientcentric formulations in a company that follows the science and turns ideas into life changing medicines Then join the Formulation Sciences department at AstraZeneca and unlock the power of what science can do.
Therapeutic Area Description:
The BioPharmaceutical Development team is a fully integrated global organization. We are passionate and proud of what we do were developing our deep pipeline of new therapeutics by delivering projects from early research to latestage development. We combine a bold ambition with huge potential. Our innovative team develops highyielding efficient production processes for even the most challenging and novel molecules. Were providing clinical products with stable formulations and developing a range of drug delivery options. In combination with advanced device development were creating medicines that patients want to use. Contribute to our growth at this exciting time and youll be immersing yourself in cuttingedge science you wont find everywhere in a way you wont find anywhere.
Research Supervisor:
Vivek Prabhu Polymers and Complex Fluids group leader NIST
In this exciting Postdoctoral Fellow position youll research and develop advanced analytical tools to characterize proteinprotein interactions in ultrahigh concentration liquid formulations. This project is supported by the Dosage Form Design and Development (DFDD) group that developspharmaceutically stable market competitive usercentric biopharmaceutical dosage forms for biologics including drug products drug delivery systems and delivery devices for clinical and commercial use. The Formulation Sciences team develops robust formulations and optimizes the drug product presentation to deliver patientcentric medicines.
Project Focus:
This project will conduct pioneering research in the development of ultrahigh concentration formulations by understanding the role of proteinprotein interactions in crowded environments. Our Postdoc will collaborate with experienced AZ interdisciplinary scientists with diverse set backgrounds and an exceptional research mentor and his team specifically aligned to the project to develop advanced scattering techniques and appropriate biophysical methods to characterize proteins at ultrahigh concentrations. This work will enable the prediction of proteinprotein interactions based on the experimental data generated and a computational model.
Supported by Monica Castellanos Associate Director at AstraZeneca youll also receive research mentorship and guidance from Vivek Prabhu Group Leader Polymers and Complex Fluids at the National Institute of Standards and Technology.
Key Duties & Responsibilities:
Our Postdoctoral Fellow will conduct groundbreaking research in a stateoftheart laboratory that is focused on the development of biotherapeutic drug substance and drug product designs formulations and fillfinish process for therapeutic proteins. You will use advanced scattering techniques to underpin the role of proteinprotein interactions and work with a crossfunctional team to develop models that enable predictions of such interactions in liquid formulations at high concentration.
Perform biophysical characterization and/or analytical assays in support of protein solubility stability elucidation of protein degradation mechanisms.
Lead and drive the project under the supervision of crossfunctional AstraZeneca team and in collaboration with external partners.
Presenting scientific findings to both internal audiences within the company and external scientific community.
Plan write publish and present highquality scientific papers and technical reports.
Essential Qualifications / Education:
PhD degree in chemistry biochemistry pharmaceutics chemical/biochemical engineering or related field
A maximum of 4 years of postdoctoral experience
Experience with scattering techniques such as static and dynamic light scattering Xray and/or neutron scattering
Extensive knowledge of biophysical characterization of proteins
Basic/working knowledge of programming/coding language and computational models
Desirable Requirements:
Knowledge of one or more of the following areas is a plus but not required: formulation development rheology spectroscopy techniques polymer physics machine learning or data science
Excellent written and oral communication skills
Strong planning organizational and time management skills
Ability to work effectively in a multidisciplinary research environment
You will work in an industryleading group with a strong publication track record while being supported by a leading external collaborator and his team. Ultrahigh concentration formulations have the potential to transform patient outcomes and drive differentiation by enabling the delivery of high doses subcutaneously. Current workflows require extensive lab experiments and time which delay the development of patientcentric stable dosage forms at high concentrations. By understanding the mechanisms driving selfassociation and proteinprotein interactions in crowded conditions a rational and efficient approach for high concentration formulation development can be established.
Length of Program guide: This opportunity is tailored for PhDqualified students aiming to undertake research within the industry potentially lasting up to three years. It is ideal for those looking to advance their careers while preserving strong connections to academia. Participants are encouraged to continue enhancing their scientific profiles through publications and conference attendance.
AZs Postdoc Programme: at AstraZeneca: is what were made of: Open Date: Apr 21 2025
Req Close Date: May 25 2025
To find out more go to: and anticipate a high volume of applicants so do not delay applying! Each applicant is individually assessed during our interview process which includes several stages. Please note that candidates may not be invited to participate in every stage depending on their fit and skills as evaluated at each step.
Salary for this role is based on years of experience after obtaining PhD is a minimum of US$99900 up to Max of US$107500 shortterm incentive. Some relocation supplements depend on distance and location at the employers discretion.
Date Posted
08May2025Closing Date
24May2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion starting with our recruitment process. We welcome and consider applications from all qualified candidates regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations please complete the section in the application form.Employment Type
Full-Time
