Global Clinical Physician Lead, Neuroinflammation, Immunology Cell Therapy

Location: Office based role in Boston Seaport MA USA

Are you a visionary expert in clinical drug development possessing the capabilities to drive a successful strategy in accelerating the development of cellular therapies for patients with immunemediated diseases Are you dedicated to revolutionizing the treatment of immunemediated diseases and creating a significant impact on patients lives Do you have a strong passion for science and substantial clinical development experience in Immunology/Neuroinflammation and CART cell therapies Do you possess both strategic and operational leadership skills If so we invite you to join us! We are currently seeking a Global Clinical Physician Lead Neuroinflammation Immunology Cell Therapy to be based in Boston Seaport.

About AstraZeneca

AstraZeneca is a global scienceled patientfocused biopharmaceutical company that focuses on the discovery development and commercialization of prescription medicines for some of the worlds most serious diseases. We are more than one of the worlds leading pharmaceutical companies.

Immunology Cell Therapy

Our ambition is to build a world class organization that accelerates the delivery of transformative cell therapies for patients with immune mediated diseases. Its our big vision that unites and inspires us. Cell therapies represent a fundamental evolution of how drugs are discovered developed and manufactured these new advanced potentially curative cellular modalities require a new development strategy to ensure their rapid availability to patients. With multiple autoimmune and inflammatory indications and clinical stage cell therapies in global development we keep pushing forward. Focusing on cuttingedge science with the latest technology to achieve breakthroughs. AZ is a place built on courage curiosity and collaboration we make bold decisions driven by patient outcomes.

What Youll Do

The Global Clinical Physician Lead Neuroinflammation holds an expert position within the new and dynamic immunology cell therapy organization at AstraZeneca. This is an exceptionally exciting and prestigious role contributing significantly to AstraZenecas global objectives and the value targets of our portfolio. Reporting directly to the Head of Immunology Cell Therapy in Boston this person will also be a pivotal member of the leadership and clinical teams working in an adaptive matrixed environment. As the Global clinical Physician Lead they will be responsible for spearheading the Neuroinflammation program with a focus on Multiple Sclerosis and related studies in immunemediated diseases. Moreover this role offers the unique opportunity to collaborate closely with crossfunctional teams at the enterprise level including Oncology Alexion and several development partners thereby enhancing the overall impact and reach of the position. The successful candidate will thrive in a fastpaced proactive cando culture be a highly effective internal and external team player as well as a strong communicator and collaborator.

Responsibilities:

• Provide expert medical and scientific input to preclinical and clinical stage assets in development for neuroinflammatory diseases and additional immunemediated diseases

• Accountable for clinical scientific aspects of the cell therapies in Neuroinflammatory indications including the benefit/risk of a product and/or asset as well as the scientific strategies for clinical components of the Target Product Profile (TPP) Target Product Claim (TPC) Clinical Development Plan (CDP) Clinical components of regulatory documents medical monitoring and ensuring timely delivery of studies.

• Lead Immunology Cell Therapy Clinical Development for neuroinflammation at internal governance interactions and with external partners (as aligned with senior manager) including Investigators key external authorities and patient advocacy groups (e.g. regulatory site CROs and KEEs).

• Closely follow medical developments within the cell therapy immune mediated diseases and disseminate information within Clinical Development and the wider organization to transform trends and emerging data into innovative clinical strategies

• Provide impactful medical strategy and cell therapy expertise to Research Translational Medicine and Commercial Partners including in the development of therapeutic area strategy

• Work closely and collaborate across early and late clinical development partner functions and wider AZ organization in Oncology and Rare disease to ensure design and delivery of clinical development plans with high quality and speed

Essential Skills/Experience:

• An MD or other equivalent degree from an accredited university or an MD or equivalent degree plus a PhD with specialty or experience in Neuroinflammation or related immunology therapeutic area ideally with cell therapy expertise.

• Postgraduate subspecialty training medical training/board certification in relevant field with a history of holding substantive clinical positions at attending/consultant level preferably at a major academic medical center

• Minimum of 5 or more years of expertise & experience in both the clinical setting and the drug development process specifically in designing clinical trials coupled with the appropriate regulatory insights.

• Extensive as a clinical trialist in Neuroinflammation ideally Multiple Sclerosis with deep knowledge of the of the landscape especially in the United States with a proven ability to engage with key sites external experts and patient partners

• Global external awareness within the therapeutic area and global regulatory environment

• Adaptive problem solving and learning and ability to navigate complex organizations and systems

• Ability to influence both high level internal and external stakeholders.

• Ability to frame clear & succinct messages and simplify complexity of decision making

• Substantial experience in early and/or late phase clinical development including handson experience in the design delivery and interpretation of multiple clinical studies.

• Thorough understanding of the full drug development process including interpretation of nonclinical data and clinical study design and execution.

• Thorough command of clinical research methodology and biostatistics principles to facilitate innovative and efficient clinical trial design and clinical development plans with datadriven decisions.

• Thorough command of FDA EMA MHRA and ICH GCP guidelines to ensure the appropriate conduct of global clinical studies in the United States Europe and rest of world.

• Attention to detail aim to generate highquality work and sense of passion and urgency to achieve team and program goals.

• Proven experience leading complex projects and working collaboratively with multiple team members regarding new strategies to ensure consistent communication.

• Track record of leading successful high performing global crossfunctional team as well as line management experience.

• Proven ability to learn new information rapidly and effectively with excellent analytical problem solving and strategic planning skills.

Desirable Skills/Experience:

• Experience in clinical development of CARTcell therapy is highly desired.

• Experience of clinical/commercial interface

• Global external awareness within the therapeutic area and global regulatory environment

• Ability to travel nationally and internationally

At AstraZeneca we trust in the science. Driven by it and united by it this is the place where extraordinary science comes alive. Its our smart thinking and patience that helps us to push the boundaries of science to deliver lifechanging medicines. If you have a true love of science and believe in its potential to redefine the possible then this is the place for you.

Join us at AstraZenecas Biopharmaceuticals R&D division and be part of a team of leading specialists driven to pursue scientific knowledge. Here we see the bigger picture and know where we can make the biggest impact. Were strong storytellers and communicators showcasing our work across the business to gain agreement and bring others on the journey with us.

Are you ready to make a greater impact Apply now!

The annual base pay (or hourly rate of compensation) for this position ranges from $265000 to $390000. Hourly and salaried nonexempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors including market location jobrelated knowledge skills and experience. In addition our positions offer a shortterm incentive bonus opportunity; eligibility to participate in our equitybased longterm incentive program (salaried roles) to receive a retirement contribution (hourly roles) and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program 401(k) plan; paid vacation and holidays; paid leaves; and health benefits including medical prescription drug dental and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired employee will be in an atwill position and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time including for reasons related to individual performance Company or individual department/team performance and market factors.

Date Posted

Closing Date