Thesis work, 30/60 credits - Exploring Imaging and Surface Analysis Techniques in Pharmaceutical Development
Thesis work, 30/60 credits - Exploring Imaging and Surface Analysis Techniques in Pharmaceutical Development
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Job Description
Are you ready to dive into cuttingedge research in pharmaceutical development Join us to enhance your expertise in imaging and surface analysis!
About AstraZeneca:
AstraZeneca is a global scienceled patientcentred biopharmaceutical company focusing on discovering developing and commercialising prescription medicines for some of the worlds most serious diseases. But were more than a global leading pharmaceutical company. At AstraZeneca were dedicated to being a Great Place to Work and empowering employees to push the boundaries of science and fuel their entrepreneurial spirit.
About the Opportunity:
As a Thesis Worker at AstraZeneca youll find an environment thats full of unique opportunities and exciting challenges. Here youll have the opportunity to pursue your areas of interest whilst equally developing a broad skillset and knowledge base to get the best out of your experience. Youll be working on meaningful projects to make an impact and deliver real value for our patients and our business.
Thesis work description:
This master thesis focuses on developing and establishing experimental and computational methodologies using two essential techniques:
- Energy Dispersive Xray Spectroscopy (EDX) in the Scanning Electron Microscope (SEM)
- Time of Flight Secondary Ion Mass Spectrometry (ToFSIMS).
The purpose of this work is to aid Global Product Development (GPD) in maximizing knowledge gain from these complementary techniques for the characterization of pharmaceutical active ingredients and formulations.
The landscape of pharmaceutical development is evolving presenting increasingly complex challenges as drug delivery systems extend beyond traditional methods. Understanding the relationship between microstructure and material properties is crucial for designing robust formulations that maintain manufacturability and drug product quality.
EDX and ToFSIMS are critical tools in this endeavor particularly in foreign particle investigations where timely laboratory work supports risk assessment and resolution of manufacturing deviations to ensure patient safety and product quality. SEMEDX provides spatially resolved elemental composition while ToFSIMS identifies and quantifies surface species often analyzed through multivariate data approaches.
Key Objectives:
- Develop Expertise in EDX and ToFSIMS Receive training and develop skills in SEMEDX (ZEISS Gemini SEM 300 with Oxford Ultim Max 100 EDX detector) and ToFSIMS (new advanced OrbiSIMS M6 Hybrid SIMS IONTOF GmbH).
- Collaborative Research Work with inhouse imaging and data/image analysis experts and collaborate with external application specialists as needed.
- Imaging Experiments Conduct imaging experiments on active pharmaceutical ingredients formulations and devices including preparation of samples for analysis.
- Identify and Quantify Composition Determine the elemental and chemical composition of specimen surfaces through EDX and ToFSIMS investigations.
- Technique Optimization Investigate the impact of various working modes and parameters on analysis results to enhance accuracy and reliability.
- Best Practice Documentation Establish and share best practices for EDX methodology within the GPD Material Design community.
- Develop Correlative Microscopy Workflows Create workflows for combining ToFSIMS and SEMEDX for comprehensive sample analysis.
- Data Analysis Techniques Combine and evaluate experimental results from both techniques using data/image analysis and multivariate approaches to enhance insights.
- Networking and Professional Growth Participate in unit and departmental meetings network with peers and gain insights into pharmaceutical development.
Structure:
- Starting: Fall 2025 (adapted after the course)
- Credits: 3060 (scope could be adjusted)
Essential Requirements:
- Ongoing masters studies within Chemistry Mathematics Physics Pharmaceutics or Materials
So whats next
Apply today and take the chance to be part of making a difference making connections and gaining the tools and experience to open doors and fulfil your potential. We cant wait to hear from you!
We welcome your application as soon as possible but ahead of the scheduled closing date 30th of May 2025. In the event that we identify suitable candidates ahead of the scheduled closing date we reserve the right to withdraw the vacancy earlier than published.
Date Posted
29apr.2025Closing Date
30maj2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion starting with our recruitment process. We welcome and consider applications from all qualified candidates regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations please complete the section in the application form.Employment Type
Full-Time
