Senior Scientist, Manufacturing Sciences â Scale Up Lab
Senior Scientist, Manufacturing Sciences â Scale Up Lab
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$ 112164 - 168246
1 Vacancy
Job Description
Senior Scientist Manufacturing Sciences Scale Up Lab
Are you driven by a passion for science and innovation Do you want to make a tangible impact by transforming ideas into lifechanging medicines At AstraZeneca we are committed to putting patients first and meeting their unmet needs globally. Join us in the Manufacturing Sciences Scale Up Lab (SUL) where we produce cell culture and purification materials for development toxicology and process scaleup studies. Collaborate with process development scientists engineers and technical transfer groups to demonstrate process scaleup and technology capabilities. This role involves working in both upstream and downstream operations offering a dynamic environment for those eager to lead and innovate.
Accountabilities
- Plan execute and troubleshoot continuous downstream operations.
- Serve as a subject matter expert on PAK BioSolutions PAK Pilot.
- Analyze and interpret process results.
- Prepare experimental proposals technical reports work guides and batch records.
- Train and guide new employees on downstream scale up lab operations.
- Represent Manufacturing Sciences and scale up lab on internal and external teams.
- Evaluate and implement new technologies and tools to improve process outcomes.
- Plan execute and troubleshoot 50L to 200L bioreactors for fedbatch and perfusion cell culture processes.
- Conduct harvest operations including continuous flow centrifuges depth filtration and TFF.
- Produce data and materials for downstream development toxicology formulation and stability studies.
Essential Skills/Experience
- Bachelor or Master of Science degree in Biology Biochemistry Bioprocess Engineering Chemical Engineering or related life sciences field.
- Relevant industry related experience: B.S. with 8 years of related experience or M.S. with 6 years of related experience
- Strong background in downstream unit operations including affinity ion exchange and viral inactivation.
- Experience operating cell culture equipment: bioreactors CIP skids and continuous centrifuges.
- Excellent communication and collaboration skills.
- Strong problem solving experimental design organizational presentation and documentation skills.
- Ability to work in a team environment or independently
- Capability to lead matrix teams.
- Willingness to work periodically on weekends.
Desirable Skills/Experience
- Understanding of engineering principles and application to bioprocessing.
- Experience culturing CHO and HEK cell lines and purification techniques of monoclonal antibodies.
- Experience working with pilot scale bioprocessing equipment.
- Programming experience ( python etc.).
- Experience in writing recipes for instrument automation.
- Fundamental understanding of key quality attributes necessary for cell culture fermentation and purification.
At AstraZeneca we are at the forefront of scientific innovation in Oncology. Our collaborative environment brings together the brightest minds from academia and industry to push the boundaries of science. We are united in our mission to transform cancer treatment and improve patient outcomes. With one of the broadest Oncology pipelines in the industry you will have the opportunity to work with novel drugs and cuttingedge technologies. Our diverse team fosters a culture of courage and curiosity empowering you to take smart risks and challenge the norm.
Ready to make a difference Join us at AstraZeneca and be part of a team that is transforming the future of medicine!
The annual base pay for this position ranges from $112164..00. Hourly and salaried nonexempt employees will also be paid overtime pay when working qualifying overtime pay offered may vary depending on multiple individualized factors including market location jobrelated knowledge skills and experience. In addition our positions offer a shortterm incentive bonus opportunity; eligibility to participate in our equitybased longterm incentive program (salaried roles)to receive a retirement contribution (hourly roles) and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program 401(k) plan; paid vacation and holidays; paid leaves; and health benefits including medical prescription drug dental and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired employee will be in an atwill position and the Company reserves the right to modify base pay(as well as any other discretionary payment or compensation program) at any time including for reasons related to individual performance Company or individual department/team performance and market factors.
Date Posted
14May2025Closing Date
29Jun2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion starting with our recruitment process. We welcome and consider applications from all qualified candidates regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations please complete the section in the application form.Required Experience:
Senior IC
Employment Type
Full-Time
