Scientist II/Senior Scientist, Analytical Development

About Capstan Therapeutics
Capstan is a biotechnology company with a mission to multiply the therapeutic possibilities for patients by developing targeted in vivo RNA technologies. Our proprietary CellSeeker tLNP platform technology is composed of novel LNPs conjugated with a recombinant protein binder such as a monoclonal antibody. tLNPs are designed to deliver payloads including mRNA or gene editing tools capable of reprogramming specific cell types in vivo. Capstans CellSeeker technology has the potential to generate transformative therapies with possible applications across a broad range of disease areas including autoimmune disorders oncology fibrosis and monogenic blood disorders.

The Opportunity
We seek a Scientist II/Senior Scientist Analytical Development to join an experienced fastpaced and collaborative team. This position will be primarily responsible for developing and optimizing analytical methods supporting the biophysical characterization of mRNAbased targeted lipid nanoparticles (tLNPs) for Capstans pipeline. Working closely with the technology development and research teams this position will support process/product understanding support expansion of the tLNP platform contribute to product investigations and build phaseappropriate protein and tLNP QC and extended characterization methods.

Responsibilities & Duties:
Develop and optimize analytical methods for characterizing tLNP drug products with a particular focus on protein protein conjugate and lipid nanoparticle analysis
Design and execute routine and nonroutine analysis supporting process/platform development stability and product characterization. Support analytical investigations into deviations and OOS/OOT results
Lead internal development through prevalidation of novel analytical methods to characterize tLNP components and product including but not limited to HPLC LCMS CE iCIEF ELISA and/or platebased assays
Support method transfer to and qualification at CDMOs
Mentor and train members of the analytical development team
Clearly communicate findings through presentations and data summaries
Author review and approve standard operating procedures protocols and reports

Requirements/Qualifications:
Generally met with a PhD with 24 years M.S. with 57 yrs or B.S with 8 years of relevant industry experience
Technical expertise with LC/CE characterization of large molecules such as antibodies/ADCs mRNA and/or gene therapy vectors
Experience with extended characterization and release/stability testing of biologics and/or lipid nanoparticles preferred
Experience drafting and reviewing technical documents such as SOP technical reports and qualification/stability protocols
Experience with method qualification and transfer preferred
Strong communication skills both written and verbal with a demonstrated capacity to thrive in collaborative teamdriven environments

Salary & Benefits:
Salary range is $130000 $1700000/year depending on experience.
Performance bonus
Employee Stock Option Program
401(k) Program including an employer matching contribution
Medical coverage
Dental coverage
Vision coverage
Short and Long Term Disability coverage
Flexible Spending Account (FSA)
Optional Dependent Care Account
Paid Time Off (PTO)
Company Paid Holidays
Paid Sick Days
Employee Assistance Program
Onsite Fully Stocked Kitchens
Alexandria Real Estate Tenant perks include gym and fitness class access discounts at affiliated restaurants and frequent onsite meals.
Fun team environment with many employee events throughout the year

If you are interested in hearing more reach out to us. We believe that each team member will impact and improve the lives of those we work with and those we work forour patients.

Capstan Therapeutics Inc. is an equal opportunity employer and does not discriminate against applicants or employees on the basis of race religion creed color ancestry national origin sex gender (including pregnancy childbirth breastfeeding or related medical conditions) gender identity gender expression sexual orientation age marital status military or veteran status medical condition disability genetic information or any other characteristic protected by applicable federal state or local laws.

In accordance with the Americans with Disabilities Act Californias Fair Employment and Housing Act and applicable local law applicants and employees with disabilities are eligible for and may request reasonable accommodations to participate in the job application or interview process and to perform the essential functions of the job unless such accommodation constitutes an undue hardship. Please contact if you need assistance completing any forms or to otherwise participate in the application process.

Unsolicited resumes sent to Capstan from recruiters do not constitute any type of relationship between the recruiter and Capstan and do not obligate Capstan to pay fees should we hire from those resumes. We ask that external recruiters and/or agencies not contact or present candidates directly to our hiring managers or employees.