Development Scientist II, Viral Vector Analytical Development

At AstraZeneca we win through the science it is at the heart of our every success. Every decision is rooted in the limitless possibilities of what science can do. We push the boundaries of science to deliver lifechanging medicines. This purpose underpins everything we do. It gives us a reason to come to work every day. It reminds us why we exist as a company. It helps us deliver benefits to patients and build new value for shareholders. It also sets the context for our employees activities and the roles of our teams partners and other collaborators. AstraZeneca has a dynamic environment that fosters collaboration and innovation. We attract top minds and we nurture and build top talent.

Introduction to role:

Are you ready to make a significant impact in the world of genomic medicine As a Development Scientist II in Viral Vector Analytical Development at Alexion youll be at the forefront of innovation working closely with the Genomic Medicine and Viral Vector Product Development groups. Collaborate with a dynamic team of scientists to develop qualify and test immunoassaybased methods to assess recombinant AdenoAssociated Viral (rAAV) vectors. Your expertise will contribute to regulatory submissions authoring technical reports and SOPs and advancing our genomic medicine portfolio. Are you up for the challenge

Accountabilities:

• Develop optimize and implement immunoassay methods to quantify manufacturing process impurities characterize capsids and assess potency of rAAV vectors.

• Craft and execute experiments review and analyze data and qualify assays in a lab setting.

• Support tech transfer of immunoassays to internal teams and external manufacturing/testing organizations for release and characterization testing; serve as subject matter authority to assist with assay troubleshooting and lab investigations.

• Develop presentations for internal and external audiences. Author and review standard operating procedures (SOPs) technical reports and assist with the preparation of analytical sections for regulatory submissions (IND BLA etc.).

• Serve as analytical lead on crossfunctional CMC teams which may include members of QC Upstream/Downstream Process Development Manufacturing QA and Regulatory.

Essential Skills/Experience:

• BS in Molecular Biology Biochemistry or related field with 8 years of relevant experience a MS with 6 years of experience or PhD with 2 years of experience

• Strong handson experience in the development qualification/validation and transfer of immunoassay (ELISA Mesoscale) methods for biological products. Handson experience with flow cytometry surface plasmon resonance or implementing automation equipment is a plus

• Demonstrated ability to apply standard office software (Excel PowerPoint Word etc.) data analysis software (Softmax Pro GraphPad etc.) and eNotebooks software

• Strong analytical attitude and problemsolving skills

• Outstanding organizational and time management skills ability to prioritize multiple demands and work efficiently with great attention to detail

• Excellent interpersonal and collaborative skills and the ability to work independently and effectively in a highly dynamic environment

• The duties of this role are generally conducted in a mixed office and lab environment. As is typical of a labbased role employees must be able with or without an accommodation to: lift 15 pounds unassisted; work comfortably in a controlled environment with and around biological infectious and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone video and electronic messaging; engage in problem solving and nonlinear thought analysis and dialogue; collaborate with others; maintain general availability during standard business hours

Desirable Skills/Experience:

• Candidates should be selfstarters comfortable with autonomy and embrace opportunities to develop new genomic medicines as part of a dynamic team within Alexion.

When we put unexpected teams in the same room we unleash bold thinking with the power to inspire lifechanging medicines. Inperson working gives us the platform we need to connect work at pace and challenge perceptions. Thats why we work on average a minimum of three days per week from the office. But that doesnt mean were not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

The annual base pay for this position ranges from $110687 to $166030. Hourly and salaried nonexempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors including market location jobrelated knowledge skills and experience. In addition our positions offer a shortterm incentive bonus opportunity; eligibility to participate in our equitybased longterm incentive program (salaried roles) to receive a retirement contribution (hourly roles) and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program 401(k) plan; paid vacation and holidays; paid leaves; and health benefits including medical prescription drug dental and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired employee will be in an atwill position and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time including for reasons related to individual performance Company or individual department/team performance and market factors.

At AstraZenecas Alexion division youll find an environment where innovation thrives. Our commitment to patients drives us to push boundaries in R&D and healthcare. With a rapidly expanding portfolio youll have the chance to grow alongside us while making a real difference in the lives of those living with rare diseases. Our culture fosters connection and collaboration empowering you to explore new ideas and develop your skills. Join us on this journey where your career is more than just a pathits an opportunity to make an impact.

Ready to take the next step Wed love to hear from you!

Date Posted

07May2025

Closing Date

Alexion is proud to be an Equal Employment Opportunity and Affirmative Action employer. We are committed to fostering a culture of belonging where every single person can belong because of their uniqueness. The Company will not make decisions about employment training compensation promotion and other terms and conditions of employment based on race color religion creed or lack thereof sex sexual orientation age ancestry national origin ethnicity citizenship status marital status pregnancy (including childbirth breastfeeding or related medical conditions) parental status (including adoption or surrogacy) military status protected veteran status disability medical condition gender identity or expression genetic information mental illness or other characteristics protected by law. Alexion provides reasonable accommodations to meet the needs of candidates and employees. To begin an interactive dialogue with Alexion regarding an accommodation please contact Alexion participates in EVerify.