Associate Scientist III, In Vitro/In Vivo Pharmacology (IVIVP)

Location: New Haven CT (onsite)

This is what you will do:

Alexion Pharmaceuticals has an exciting opportunity for an Associate Scientist III position within the In Vitro and In Vivo Pharmacology team located at our vibrant New Haven Center of Excellence. This role primarily involves the independent design development and execution of a range of routine and special tissue analyses within our preclinical histology lab (nonregulated environment). The successful candidate will be an intellectually curious and datadriven selfstarter with strong technical and problemsolving skills and demonstrated histology expertise. This position will play an integral role in selecting and characterizing innovative and effective new molecules for treating rare diseases.

You will be responsible for:

• Independently plan and execute both routine and complex tissue staining. This involves evaluating biodistribution target engagement and efficacy in gene therapy candidates across different species.

• Optimize troubleshoot and perform tissuebased assays (IHC/ISH) with minimal supervision using the Leica Bond Rx to characterize disease progression in preclinical models identify clinically meaningful endpoints and inform the strategy for indication selection.

• Scan and QCs slides in brightfield and fluorescent mode.

• Coordinate pathological reviews and manage external histological activities conducted at qualified CROs.

• Present data and provide recommendations in internal department meetings project cross functional team sessions and Researchwide meetings to discuss findings and subsequent actions.

• Explore new technologies suggest process improvements and acquire new skills and knowledge to foster innovation.

• Oversee the operation of histology and imaging equipment and coordinate maintenance to ensure optimal performance.

You will need to have:

• B.S. 47 years or M.S. 24 years of experience in histology or biological sciencesin an academic medical or pharmaceutical/biotechnology environment

• Experience in histology immunohistochemistry immunofluorescence in situ hybridization scanning and image data management experience is crucial for this position. This includes proficiency in staining techniques troubleshooting staining and processing issues. Basic knowledge of image analysis and pathology is essential for this position.

• Strong skills in independently designing executing and critically analyzing experiments to facilitate datadriven decisions.

• Capability to prioritize and manage deliverables effectively based on project impact.

• Experience in developing executing and troubleshooting immunoassays for both in vitro and ex vivo samples.

• Strong verbal and written communication skills and exemplary organizational practices

• A commitment to collaboration and embracing a diverse and inclusive team culture is essential

• The duties of this role are generally conducted in a lab environment. As is typical of a labbased role employees must be able with or without an accommodation to: lift/carry 15/30 pounds unassisted/assisted; work comfortably in a controlled environment with and around biological infectious and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone video and electronic messaging; engage in problem solving and nonlinear thought analysis and dialogue; collaborate with others; maintain general availability during standard business hours; position may require occasional onsite weekend work. In addition employees in this role must be able with or without an accommodation to: pass a medical evaluation; wear a respirator while maintaining a tightfitting seal to the face.

We would prefer for you to have:

• An established handson in vivo skill set including compound administration anesthesia use blood and tissue collection

• Experience with dissection tissue harvesting and processing

• Experience with AAV and/or LNP screening studies

• Experience with data management and analysis systems i.e. HALO

• Preclinical expertise with in vivo imaging modalities or functional/behavioral endpoints

• Experience with electronic notebook documentation practices

• Experience with CRO management

• Experience with graphic softwareand statistical analysis

• Enthusiasm for proposing new target ideas and novel technology platforms

Date Posted

05May2025

Closing Date

24May2025Alexion is proud to be an Equal Employment Opportunity and Affirmative Action employer. We are committed to fostering a culture of belonging where every single person can belong because of their uniqueness. The Company will not make decisions about employment training compensation promotion and other terms and conditions of employment based on race color religion creed or lack thereof sex sexual orientation age ancestry national origin ethnicity citizenship status marital status pregnancy (including childbirth breastfeeding or related medical conditions) parental status (including adoption or surrogacy) military status protected veteran status disability medical condition gender identity or expression genetic information mental illness or other characteristics protected by law. Alexion provides reasonable accommodations to meet the needs of candidates and employees. To begin an interactive dialogue with Alexion regarding an accommodation please contact Alexion participates in EVerify.