Senior/Principal Laboratory Research Scientist: Metabolomics & Lipidomics Specialist
Senior/Principal Laboratory Research Scientist: Metabolomics & Lipidomics Specialist
Employer Active
Job Alert
You will be updated with latest job alerts via email
Share
Job Alert
You will be updated with latest job alerts via email
Job Description
Salary for this Role:
SLRS level from 45700 per annum plus benefits
PLRS level from 55555 per annum plus benefits.
The role is advertised as a Senior / Principal Laboratory Research Scientist; the appropriate level will be assigned to the successful candidate subject to skills and experience.
Job Title:
Senior/Principal Laboratory Research Scientist: Metabolomics & Lipidomics SpecialistReports to:
James MacraeClosing Date:
23/May/2025 23.59 GMTJob Description:
Job title: Senior/Principal Laboratory Research Scientist: Metabolomics & Lipidomics Specialist
Details of the role: Permanent fulltime. Working pattern: Monday Friday.
Salary: SLRS level from 45700 per annum plus benefits. PLRS level from 55555 per annum plus benefits. The role is advertised as a Senior / Principal Laboratory Research Scientist; the appropriate level will be assigned to the successful candidate subject to skills and experience.
Application closing date: 23/05/25 23:59 GMT
About us
The Francis Crick Institute is Europes largest biomedical research institute under one roof. Our worldclass scientists and staff collaborate on vital research to help prevent diagnose and treat illnesses such as cancer heart disease infectious diseases and neurodegenerative conditions.
The Crick is a place for collaboration innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with stateoftheart infrastructure cuttingedge facilities and a creative and curious culture. Weve removed traditional boundaries of departments divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out highquality pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.
About the role
This role in the Metabolomics Scientific Technology Platform (STP) will cover both targeted and discovery metabolomics in the context of biological research. The post provides a unique opportunity to work with cutting edge metabolomics techniques and to become deeply involved in the diverse biological research across the Crick.
Key elements of the role will include LCMS based metabolomics and lipidomics including independent operation of the stateoftheart LCMS instrumentation (most notably Thermo Orbitrap and Agilent triple quadrupole instruments) along with GCMS studies too. The role will offer an opportunity to be involved in a broad range of research topics from clinical cohort discovery studies to metabolic pathway activity analysis of in vitro models. Analytical chemistry techniques used in the lab are equally wideranging from intricate stable isotope labelling studies to drug mode of action studies.
The post holder will drive projects in collaboration with Crick research groups and will be expected to take projects from initial concept and design through metabolite extraction and sample preparation and onto data acquisition and analysis.
Innovation including development and implementation of new methods is a central remit of the STP; the post holder will be required to identify areas of need and lead method development accordingly.
What you will be doing
As an S/PLRS at the Crick you will:
Metabolomics lipidomics and mass spectrometry operations (40%). Efficient operation and maintenance of mass spectrometers particularly liquid chromatographymass spectrometry (LCMS) but also gas chromatographyMS (GCMS). Effective performance and development of in houseestablished metabolomics procedures including generation and extraction of metabolomics/lipidomics samples and data acquisition. This includes experimental design implementation of stable isotope labelling techniques and development of novel mass spectrometry techniques as appropriate.
Data analysis (35%). Effectively use data analysis software to process raw mass spectrometry data and analyse both targeted and largescale metabolomics datasets including statistical analysis (i.e. univariate and multivariate analyses); this will include stable isotope labelling feature identification and production of processed analysed MS data in a format appropriate for presentation and publication.
Training (15%). The post holder will be responsible for training other Crick researchers in the operation of the LCMS & GCMS instrumentation. This will include training in sample preparation data acquisition and data analysis.
Laboratory management (10%). The post holder will be responsible for successful day to day operation of the laboratory with roles including maintenance of safety standards purchasing and general organisation among others.
About you
The essential criteria you will bring
Ph.D. or equivalent in Metabolomics Biochemistry Analytical Chemistry Statistics Mathematical Modelling or other relevant related discipline.
Evidence of significant experience in metabolomics (including lipidomics).
Evidence of significant experience in operation maintenance and troubleshooting of hyphenatedmass spectrometry (in particular LCMS & GCMS).
Experience in performance of metabolomics/lipidomics experiments (including experimental design metabolite extraction sample preparation data acquisition and method development). Stable isotope labelling experience is desirable but not essential.
Experience in mass spectrometry and metabolomics/lipidomics data analysis and statistics (including targeted and profiling approaches and concepts such as univariate and multivariate analyses power calculations and significance) and use of data analysis software and workflow packages.
Knowledge of experimental design and metabolomics procedures in the context of large cohort studies.
Ability to work with daytoday independence with good oral and written communication skills.
Open and interactive with line manager laboratory colleagues and peers.
Organisational and timemanagement skills to be able to perform to strict deadlines.
To see the complete job description click here.
To learn more about Metabolomics click here.
About Working at the Crick
Our values
Everyone who works at the Crick has a valuable role to play in advancing the Cricks mission and shaping our culture:
We arebold. We make space for creative dynamic and imaginative ideas and approaches. Were not afraid to do things differently.
We areopen. Were highly collaborative and interactive and make sure our activities are visible to the outside world.
We arecollegial. We show respect for one another work cooperatively and support the wider community.
At the Francis Crick Institute we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued respected and empowered to succeed regardless of their background identity or personal circumstances. We actively encourage applications from individuals of all genders ethnicities abilities and experiences. We are a Disability Confident: Committed employer and you will be asked as part of the process if you wish to apply under the scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e. would like to apply by phone or post)please email:
To find out more about life at the Crick click here.
What will you receive
At the Francis Crick Institute we value our team members and are proud to offer an extensive range of benefits to support their wellbeing and development:
Visas: Applicants for this role will be eligible for sponsorship to work in the UK.
Generous Leave: 28 days of annual leave plus three additional days over Christmas and bank holidays.
Pension Scheme: Defined contribution pension with employer contributions of up to 16%.
Health & Wellbeing:
24/7 GP consultation services.
Occupational health services and mental health support programs.
Eye care vouchers and discounted healthcare plans.
WorkLife Balance:
Backup care for dependents.
Childcare support allowance.
Annual leave purchase options.
Crick Networks offering diverse groups support community and inclusive social events.
Perks:
Discounted gym memberships biketowork scheme and shopping discounts.
Subsidised onsite restaurant and social spaces for team interaction.
Development & Recognition: Comprehensive training mentoring and a pay structure based on skills and experience.
Required Experience:
Staff IC
Employment Type
Full-Time
