Scientific Associate I

Union: NonUnion
Site: Princess Margaret Cancer Centre MaRS Tower
Department: Princess Margaret Research Institute 
Reports to: Principal Investigator
Work Model: OnSite
Hours: 35 hours per week
Salary: $67465 $82545 per annum (To commensurate with experience and consistent with UHN compensation policy)
Shifts: MondayFriday
Status: Permanent Fulltime
Closing Date: June 1 2025

Position Summary:

The Myc oncoprotein is dysregulated in most human cancers and is a key regulator of gene transcription binding to 10% of the human genome to drive biological activities associated with the hallmarks of cancer. Successfully targeting MYC would represent a breakthrough in cancer therapy but due to the intrinsically disordered nature of the MYC protein it has evaded classic drug development approaches for several decades. Our lab has recently had a breakthrough and identified several proteins that interact with MYC. These data provide an unprecedented opportunity to i) better understand MYC regulation and function as a potent cancer driver and ii) develop antiMYC activity therapies by blocking critical MYCprotein interactions. This novel line of research has enormous potential to radically advance new knowledge and make a lasting impact to patients and their families.

We are searching for a highly motivated Scientific Associate with a PhD in a related discipline such molecular biology or biochemistry. This project will consist of validating and characterizing novel MYCprotein interactions at the cellular and tumor levels with a focus on proteins that are essential to MYC oncogenic function. The successful candidate will be working at the Princess Margaret Cancer Centre and will benefit from a highly collaborative and interdisciplinary research team.

Duties:

• Conduct proteinprotein interaction assays such as proximity ligation assay coimmunoprecipitation
• Analyze proteinDNA interactions using Chromatin Immunoprecipitation followed by qPCR or sequencing (ChIPseq)
• Perform analyses of gene expression including RNAseq EU incorporation
• Assay MYCprotein complexes regulating gene transcription by a variety of methods
• Have strong computational skills to enable genomic analyses and data integration
• Work with databases that enable our research such as Encode and DepMap.
• Understand the stateoftheart at both the methodological and biological levels
• Report results both in writing and orally to individuals as well as collaborative groups

Qualifications :

• PhD in molecular biology biochemistry or related discipline
• Expertise in the area of gene transcription and proteinprotein interaction
• Comprehensive experience in using and developing tumor models based in tissue culture and mice
•  Work well independently as well as with others as part of a team
• Excellent problem recognition and problemsolving
• Excellent verbal and written communication skills
• Excellent interpersonal skills
• Excellent organizational and time management skills
• Ability to set priorities and work independently with accuracy in a fastpaced multitasking environment

Additional Information :

Why join UHN

In addition to working alongside some of the most talented and inspiring healthcare professionals in the world UHN offers a wide range of benefits programs and perks. It is the comprehensiveness of these offerings that makes it a differentiating factor allowing you to find value where it matters most to you now and throughout your career at UHN.

• Competitive offer packages
• Government organization and a member of the Healthcare of Ontario Pension Plan (HOOPP access to Transit and UHN shuttle service
• A flexible work environment
• Opportunities for development and promotions within a large organization
• Additional perks (multiple corporate discounts including: travel restaurants parking phone plans auto insurance discounts onsite gyms etc.)

Current UHN employees must have successfully completed their probationary period have a good employee record along with satisfactory attendance in accordance with UHNs attendance management program to be eligible for consideration.

All applications must be submitted before the posting close date.

UHN uses email to communicate with selected candidates.  Please ensure you check your email regularly.

Please be advised that a Criminal Record Check may be required of the successful candidate. Should it be determined that any information provided by a candidate be misleading inaccurate or incorrect UHN reserves the right to discontinue with the consideration of their application.

UHN is an equal opportunity employer committed to an inclusive recruitment process and workplace. Requests for accommodation can be made at any stage of the recruitment process. Applicants need to make their requirements known.

We thank all applicants for their interest however only those selected for further consideration will be contacted.

Remote Work :

No

Employment Type :

Fulltime