Principal Scientist Analytical Development - Oligonucleotides Peptides
Principal Scientist Analytical Development - Oligonucleotides Peptides
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$ 136000 - 204000
1 Vacancy
Job Description
Job Description
General Summary:
As Vertex continues to expand its pipeline in our commitment to serving patients we are offering an exciting opportunity to join our Analytical Development team. We are actively seeking an analytical project leader to support small molecules oligonucleotides peptides and conjugated therapeutics in Boston. This newly created position will be responsible for all aspects of analytical development related to both drug substance and drug product components of their assigned projects. The successful candidate will contribute significantly to advancing a product from the earliest stages of clinical development to marketing approval.
Key Duties and Responsibilities:
- Project Oversight: Oversee all analytical deliverables required to support clinical progression for assigned projects including IND/IMPD submissions and information requests as well as represent Analytical Development on crossfunctional project teams. Manage analytical activities and timelines internally and externally at CROs/CDMOs.
- Strategy Development: Develop align and execute analytical project team plans and strategies to support drug substance and drug product development.
- Collaboration: Collaborate with all CMC functions and CMC leadership to develop strategies and deliver on key objectives; including managing matrixed analytical support of process and formulation activities.
- Technical Leadership: ensure successful method development/validation release and stability testing of drug substance and drug product.
- Mentorship: Mentor and train team members on laboratory practices and modality specific analytical techniques.
Knowledge and Skills:
- Demonstrated leadership experience in a pharmaceutical or biotechnology setting.
- CMC experience in preclinical and clinical development of small molecules oligonucleotides peptides and/or conjugated therapeutics.
- Exceptional organizational communication leadership and project management skills.
- Strong knowledge and experience with cGMPs and regulatory guidelines.
- Expertise with analytical techniques used in oligonucleotide and peptide therapeutics such as LCMS IPRPLC IEX sequencing and peptide mapping.
Education and Experience:
- Ph.D. with 4 years Masters degree with 7 years or BS degree with 10 years of relevant experience within the pharmaceutical industry with an expertise in the development of small molecules oligonucleotides and/or peptides.
Pay Range:
$136000 $204000Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors including skills competencies experience and other jobrelated factors permitted by law.
At Vertex our Total Rewards offerings also include inclusive marketleading benefits to meet our employees wherever they are in their career financial family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical dental and vision benefits to generous paid time off (including a weeklong company shutdown in the Summer and the Winter) educational assistance programs including student loan repayment a generous commuting subsidy matching charitable donations 401(k) and so much more.
Flex Designation:
OnSite DesignatedFlex Eligibility Status:
In this OnSite designated role you will work five days per week onsite with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertexs Policy on Flex @ Vertex Program and may be changed at any time.
Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and nondiscrimination for all employees and qualified applicants without regard to a persons race color sex gender identity or expression age religion national origin ancestry ethnicity disability veteran status genetic information sexual orientation marital status or any characteristic protected under applicable law. Vertex is an EVerify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager or contact Talent Acquisition at
Required Experience:
Staff IC
Employment Type
Full-Time
