Senior Expert Data Science Make-on-Demand Cheminformatics AI
Senior Expert Data Science Make-on-Demand Cheminformatics AI
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Job Description
Job Description Summary
The mission of Novartis is to reimagine medicine and our team exemplifies that mission by consistently pushing the boundaries of drug discovery technology and data science. We interface with biologists geneticists chemists and computational experts daily to execute complex collaborations and bring firstinclass and bestinclass to patients with urgent unmet need. We thrive in the earliest phases of drug discovery partnering with diverse disease areas to nominate the next generation of drug targets and modalities as well as elucidate complex biological mechanisms and sites of action.To extend our impact were seeking a creative passionate and tenacious scientist to join the data science team in Discovery Sciences (DSc) at Novartis Biomedical Research (BR). If you want to make a difference in the field of early drug discovery and want to join our dynamic and collaborative team we encourage you to apply today.
Job Description
Major accountabilities:
Champion MakeonDemand (MoD) workflows and apply and develop computational strategies and workflows that accelerate hit finding activities
Develop synthon based search strategies to allow teams to leverage ever increasing virtual spaces without having to rely on brute force searches of fully enumerated spaces
Contribute to the design of internal Low Molecular Weight (LMW) and DNA Encoded libraries in order to fully harness the potential of MoD during hit finding.
Leverage core expertise in cheminformatics computational chemistry and data science to generate and navigate virtual chemical spaces build predictive models collaborate with project teams to accelerate early drug discovery projects.
Minimum Requirements:
PhD with a cheminformatics computational chemistry or physics focus; or alternatively a degree in a related subject e.g. chemistry chemical biology computer science or data science) in combination with the equivalent experience applying computational tools in life science / drug discovery setting.
Hands on experience with cheminformatic workflows and familiarity with descriptors and machine learning (ML) in the context of cheminformatics.
Excellent scientific communication including the ability to present complex data science concepts in digestible terms to diverse scientific audiences while leveraging innovative data visualization.
Demonstrated ability to work as part of an interdisciplinary team (i.e. biologists chemists data scientists) with proactive and resultsoriented communication skills. Dedication to promoting mutual respect empathy and positivity in diverse professional settings.
Expertise working in Linux high performance computing and cloud environments.
Expertise in Python scientific stacks familiarity with best practices in computational reproducible research version control testing documentation).
Nice to have:
Familiarity with structurebased and ligandbased approaches
Experience with some of the following: ligand protein docking generative chemistry deep learning ligand protein cofolding
Familiarity with Large Language Models (LLMs)
Experience or familiarity with organic synthesis
Experience designing libraries of small molecules
Experience using synthons and transformations to generate virtual spaces or to interrogate virtual spaces
Novartis is committed to building an outstanding inclusive work environment and diverse teams representative of the patients and communities we serve.
Skills Desired
Apache Hadoop Applied Mathematics Big Data Curiosity Data Governance Data Literacy Data Management Data Quality Data Science Data Strategy Data Visualization Deep Learning Machine Learning (Ml) Machine Learning Algorithms Master Data Management Proteomics Python (Programming Language) R (Programming Language) Statistical ModelingRequired Experience:
Senior IC
Employment Type
Full-Time
