Cell Assay Senior Scientist - Blue Sky Kinases
Cell Assay Senior Scientist - Blue Sky Kinases
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$ 104000 - 186160
1 Vacancy
Job Description
The Worlds Brightest Minds Always Innovate
At St. Jude Childrens Research Hospital we know what can be achieved when the brightest scientific minds face the fewest barriers. Thats why we provide worldclass facilities. Stateoftheart technologies. Extraordinary support. And a collaborative benchtobedside environment where you can see firsthand how your science translates into survival for the children we serve. Quite simply at St. Jude we encourage you to dream big and stop at nothing when it comes to finding cures and saving children.
The candidate will work in a team based environment to integrate novel structural insights with cell biology to study multiple kinase targets in a dynamic comprehensive interdisciplinary initiative at theDepartment of Structural BiologySt. Jude Childrens Research Hospital.
The candidate will use their molecular biology biochemistry and cell culture skills to support signal transduction pathway analyses and novel kinase inhibitor development to understand how different kinase conformations contribute to the transduction of signals within a cell.
Responsibilities:
- Design develop and perform cellular assays to characterize novel kinase conformations and inhibitors.
- Interpret analyze and communicate cellbased assay results with team collaborators aiding in the optimization and development of these hits.
- Perform and quantify bioanalytical and cellbased assays.
- Immunoassays (e.g. ELISA AlphaLISA Mesoscale discovery).
- Western blots proteinprotein interaction assays flow cytometry reporter assays.
- Generate tissue culturecell lines using CRISPR or similar technologies.
- Develop and execute targetspecific assays pathwayspecific assays reporter assays and phenotype assays for inhibitor characterization.
- Tissue culturecell line generation employing CRISPR or similar technologies.
- Contribute to assay development process including designing optimizing and conducting medium and high throughput cellular assays.
- Perform statistical analysis and proficiently use graphing software or R scripts.
Successful Candidates Will Have:
- Experience in analysis of protein kinases/phosphorylation dependent signaling mechanisms and/or cellular signaling pathways.
- Handson experience with cellbased assay techniques for studying cancer cell vulnerabilities and targets mechanisms of action including but not limited to proliferation assays microscopy protein and RNA analysis flow cytometry and qPCR.
- Expertise in genetic (CRISPR and RNAi) and pharmacological (small molecules) perturbations.
- Proficiency in experimental design assay development of experiments data analysis interpretation and presentation.
- Experience with lab automation for HT assays.
- Experience with mouse models is preferred but not essential.
Competencies:
- Creative and resultdriven with strong critical thinking and quick learning abilities.
- Hardworking wellorganized flexible and capable of multitasking efficiently in a fastpaced environment.
- Able to work collaboratively and efficiently in teams with diverse backgrounds and opinions.
- Ability to prioritize work and complete assignments promptly.
Minimum Education and/or Training:
- Bachelors degree in relevant scientific area is required for either level.
Minimum Experience:
- Ten 10 years of relevant work experience is required with a Bachelors degree.
- Eight 8 years of relevant experience is required with a Masters degree.
- Five 5 years of relevant work experience is required with a PhD.
Better at Work. Better at Life.
When you work at St. Jude youll join a highly collaborative work culture that inspires you every day to be your best. With opportunities for learning and growth you can shape a career path that is right for you while also enjoying all the benefits and stability of working for a worldclass institution. This includes worklife balance with generous paid timeoff and oncampus conveniences that make life a little easier. Join us and youll quickly see why St. Jude is consistently ranked by our employees on Glassdoor as a Best Place to Work.
Have More in Memphis
Get the best of bigcity amenities mixed with all the charm of a smalltown feel when you live in Memphis. From our worldrenowned music scene to our eclectic mix of food and people. Memphis is a place our employees are proud to call home. Our region enjoys a cost of living more than 20 lower than the national average and our state places no personal income tax on wages. Plus Memphians spend five hours less per year in their daily commute compared to the national average. Learn how you can Have More in Memphis.
Compensation
In recognition of certain U.S. state and municipal pay transparency laws St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets experience and training licensure and certifications and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $104000 $186160 per year for the role of Cell Assay Senior Scientist Blue Sky Kinases.Explore our exceptional benefits!
No Search Firms
St. Jude Childrens Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.
Required Experience:
Senior IC
Employment Type
Full-Time
