Principal Scientist Cardiometabolic Diseases Inflammation and Obesity - Translational Biology
Principal Scientist Cardiometabolic Diseases Inflammation and Obesity - Translational Biology
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Job Description
About Us
Valo Health is a technology company that is integrating humancentric data and AIpowered technology to accelerate the creation of lifechanging for more patients faster. Valo was created with the belief that the drug discovery and development process can and should be faster and less expensive with a much higher probability of success. We are using models early to fail less often executing clinical trials to add valuation to the company and generating fitforpurpose data to feed back into Valos Opal Computational Platform as we reinvent drug discovery and development from the ground up. Disease doesnt wait so neither can we.
We are a multidisciplinary team of experts in science technology and pharmaceuticals united in our mission to achieve better for patients faster. Valo is committed to hiring diverse talent prioritizing growth and development fostering an inclusive environment and creating opportunities to bring together a group of different experiences backgrounds and voices to work together. We achieve the widestranging impact when we leverage our broad backgrounds and perspectives to accelerate a new frontier in health. Valo seeks to become the catalyst for the pharmaceutical industry and drive the digital transformation of the industry. Are you ready to join us
About the Role...
Valo is looking for a Principal Scientist to play a pivotal role in executing the wet lab translational biology plans for targets that have been identified using Valos humancentric Opal computational platform. This position requires deep expertise in the biology of obesity and/or cardiometabolic disease ideally with additional experience in inflammation. This ideal candidate will have experience in drug discovery and a passion for translating human data insights to develop new therapies for complex diseases at the bench. In this role you will be responsible for helping to design and execute program related translational biology plans to demonstrate in vitro/in vivo correlation including PK/PD profiling of cells and tissues whether by omics imaging or other targeted and untargeted methods and demonstration for key cellular or in vivo biomarkers. This role will be critical to build confidence in translation of candidate drug targets to diseases of interest and in supporting their progression through the pipeline. You will closely collaborate with subject matter experts computational scientists other wetlab biologists and tissueengineers. You will contribute to delivering validation data packages from your efforts and presenting to internal and external stakeholders. You will participate as a subject matter expert collaboration with Valos target discovery team where appropriate.
What Youll Do
- Develop and Execute strategies to demonstrate in vivo/in vitro correlation in cells and in various animal models.
- Work with CROs and project leadership to design and execute in vivo pk/pd and efficacy experiments.
- Design and execute experiments to confirm relevance of biomarkers for novel targets and build biomarker strategies to support program progression through various stages.
- Perform experiments and generate data in laboratory in collaboration with Valos tissue and cell model experts and where appropriate leveraging CROs to support ongoing drug discovery projects.
- Build functional assays in vitro and exvivo to enable interrogation of novel drug targets.
- Provide biology leadership on various program and project teams.
- Provide thought leadership and guidance within your project teams on obesity T2D Inflammation and/or cardiovascular disease biology staying abreast of emerging trends and advancements in the fields.
What You Bring
- A PhD in Biological Sciences or related field with 8 years of experience (may include postdoctoral experience; or MS with 12 years or BS with 14 years) and deep expertise in one or more of the following areas: inflammation obesity diabetes liver biology skeletal muscle biology adipose tissue biology inflammation. An ideal candidate would have experience working at the interface between metabolism and inflammation.
- Expertise with in vitro and in vivo systems and ability to work across and develop different systems as needed.
- Experience working with and managing projects at external vendors/CROs.
- Experience in preclinical drug discovery programs and with target validation projects.
- Strong oral and written communication presentation and interpersonal skills.
- Experience in collaborating with multidisciplinary teams.
You May Also Bring
- Experience with immunology techniques such as flow cytometry ELISA MSD.
- Experience generating samples for multiomics profiling.
- Experience with multicellular invitro systems or organoids.
More on Valo
Valo Health LLC (Valo) is a technology company built to transform the drug discovery and development process using humancentric data and artificial intelligencedriven computation. As a digitally native company Valo aims to fully integrate humancentric data across the entire drug development life cycle into a single unified architecture thereby accelerating the discovery and development of lifechanging while simultaneously reducing costs time and failure rates. The companys Opal Computational Platform is an integrated set of capabilities designed to transform data into valuable insights that may accelerate discoveries and enable Valo to advance a robust pipeline of programs across cardiovascular metabolic renal oncology and neurodegenerative diseases. Founded by Flagship Pioneering and headquartered in Lexington MA. Valo also has offices in New York NY. To learn more visit .
Required Experience:
Staff IC
Employment Type
Full Time
