Senior Scientist II Biologics Analytical Development

AbbVies Biologics CMC Analytical Research and Development Group in South San Francisco has an exciting opportunity for a Senior Scientist II to join a dynamic team of scientists responsible for all aspects of CMC analytical development required to move biologic candidates from discovery into and through clinical studies.

In this labbased role you will utilize your knowledge of protein chemistry and expertise in chromatography (LC) and capillary electrophoresis (CE) to contribute to development of AbbVies growing pipeline of clinical stage biotherapeutics which include novel bispecific constructs antibodydrug conjugates and monoclonal antibodies. You will characterize and investigate attributes of biologic drug candidates to provide product and process understanding as well as develop innovative analytical methods that provide deeper insights into protein biotherapeutics across the development spectrum from candidate liability screening to process development to clinical development.

Key Responsibilities Include:

• Independently develop state of the art capillary electrophoresis and HPLC methods to characterize biotherapeutic proteins and their associated variants and impurities.
• Characterize posttranslational modifications and structureactivity relationships of products under development.
• Develop innovative approaches to solve difficult analytical challenges.
• Represent the Biologics CMC Analytical Research and Development Group as a subject matter expert on cross functional project teams.
• Develop qualify/validate and transfer fitforpurpose QC release and stability methods.
• Provide technical support and oversight for QC testing occurring at internal and external GMP laboratories.
• Plan and author characterization comparability and quality sections of regulatory submissions (INDs/CTDs).
• Engage and influence the broader scientific community through publications and poster and oral presentations at industry conferences.

Qualifications :

• Bachelors Degree or equivalent education and 12 years of experience Masters Degree or equivalent education and 10 years of experience PhD and 4 years of experience.
• Must possess a solid understanding of protein chemistry and biochemistry particularly as it relates to biotherapeutic protein drug development.
• Demonstrated proficiency in developing and performing capillary electrophoresis and HPLC methods as they apply to protein characterization.
• Experience with CMC analytical development of monoclonal antibodies or related biotherapeutic proteins is preferred but not required.
• Proven record of advanced technical/scientific achievement and innovation.
• Quality control and/or GMP experience is beneficial.
• Must have strong written and verbal communications skills.
• Must be capable of working in a fastpaced collaborative environment and managing multiple concurrent projects with a high degree of independence.

Additional Information :

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: 

• Onsite position located at AbbVies ABA site in South San Francisco CA. 
• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location and we may ultimately pay more or less than the posted range. This range may be modified in the future.
• We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our shortterm incentive programs. 
• This job is eligible to participate in our longterm incentive programs

Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of any bonus commission incentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole and absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. 

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