Scientist l Biologics LCMS Bioanalysis QTAS
Scientist l Biologics LCMS Bioanalysis QTAS
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Job Description
AbbVie Inc is embracing new paradigms and technologies to develop novel and lifechanging therapies across a diverse range of therapeutic areas. The Quantitative Translational ADME Sciences (QTAS) department at AbbVie is seeking a highly motivated and energetic bioanalytical scientist to join the biologics bioanalysis characterization and proteomics (BBCP) group. The main function of this position will be supporting LCMS (liquid chromatographymass spectrometry) based bioanalysis and method development of biologics entities specifically for multispecific antibodies and antibody drug conjugates (ADCs) etc. The ideal candidate will be experienced in the
optimization and implementation of LCMSbased bioanalytical methods to support preclinical in vivo PK and TK studies. The candidate will be responsible for routine sample preparation method development instrument maintenance data analysis writing reports and presenting data at internal and external meetings.
Responsibilities:
- Perform highthroughput quantitative bioanalysis of biologic therapeutics in biofluids and tissues for PK/PD and TK studies.
- Optimize and develop bioanalytical methods for quantifying multispecific antibodies/drug conjugates in biological matrices using LCMS MRM assays.
- Operate and maintain LCMS and automation instruments; handle troubleshooting as needed.
- Maintain electronic laboratory notebooks (ELN) and manage study documentation in the Laboratory Information Management System (LIMS).
- Collaborate with project representatives and bioanalytical scientists with different backgrounds (LCMS and LBA). Present work internally and externally.
Qualifications :
- Degree in chemistry pharmacology or other related fields. BS with 5 years or MS with 2 years in a pharmaceutical industry setting with a focus on bioanalysis and mass spectrometry.
- Motivated with a strong technical background in highthroughput LCMS assay operations.
- Highly organized and attention to detail.
- Direct experience with multispecific antibodies and ADCs including bioanalysis in biological matrices and method development for evaluating in vivo stability is a must.
- Experience with immuneaffinity purification and sample preparation using automation systems (e.g. TECAN AssayMap Bravo) is required.
- Broad knowledge in analytical separation science and handson experience with Agilent
- UPLC and SCIEX Triple Quad mass spectrometer is required. Experience with high resolution mass spectrometers (TOF or orbitrap) is a plus.
- Proficiency in managing LIMS software for sample data and workflow management is preferred.
- Strong data analytical skills: familiarity with Skyline Analyst and SCIEX OS for data processing is preferred.
- Excellent verbal and written communication skills strong organizational abilities and the ability to work independently and thrive in a matrix team environment.
- Desire to excel in a fastpaced environment with strong problemsolving skills and the ability to prioritize tasks and meet deadlines effectively.
Additional Information :
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location and we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our shortterm incentive programs.
Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of any bonus commission incentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole and absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
US & Puerto Rico only to learn more visit & Puerto Rico applicants seeking a reasonable accommodation click here to learn more:
No
Employment Type :
Fulltime
Employment Type
Full-time
