Senior Scientist I
Senior Scientist I
Employer Active
Job Alert
You will be updated with latest job alerts via email
Share
Job Alert
You will be updated with latest job alerts via email
Job Description
About DJS AbbVie:
At DJS AbbVie we aspire to create new medicines to improve the lives of patients with serious immunological diseases and cancers. We achieve this by using our proprietary HEPTAD platform to deliver therapeutic antibodies against complex and intractable membrane protein targets. As a biotech company within AbbVie we combine the agility team spirit and scientific focus of a biotech with the reach and vision of a global pharmaceutical company. We have discovered a number of drug candidates to date and continue to grow our exciting portfolio.
About the role:
This role will span mechanistic biology pharmacology target selection and antibody discovery. The primary focus will be to develop an understanding of the background biology and signal transduction pathways of the proteins targeted by candidate antibodies and then design and conduct experiments using in vitro systems to dissect the pharmacology and mechanism of action of the candidate antibodies. This will inform disease positioning rational drug combinations dose selection clinical biomarker selection and future target selection. In line with this the role will connect back to our discovery group inputting into the identification of targets for new discovery programs.
The successful applicant should have a track record of immunology research in industry or academia. They will be an experimentalist skilled at interpreting insights from the literature and translating them into actionable experiments. Daytoday they will work collaboratively in project teams who are focussed on different programs at different stages of the R&D process. They should therefore be keen to get involved with all aspects of research at DJS. This will necessitate clear communication and excellent time management. Alongside organisational skills however they must enjoy adapt to changing priorities in a fastpaced environment.
At DJS we want to foster innovative scientists performing drugdiscover led by cuttingedge science. In this role the successful candidate will develop knowledge across mechanistic biology pharmacology and early discovery with visibility across our portfolio of early discovery through to clinicalstage drug candidates. As such this role will bring many career development opportunities. These are extended further by our unique position within AbbVie which allows access into a much broader worldleading drug development pipeline and learnings about broader pharmaceutical business.
Successful applicants key responsibilities
- Bringing energy enthusiasm and positivity to the company
- Engaging with the literature to build deep understanding of target biology
- Establish and implement in vitro experimental models for assessing antibody pharmacology and mode of action
- Perform critical laboratory experiments and analysis to develop and extend existing methodologies
- Mentor junior scientists from the benchside in new and novel immunological techniques and methodologies
- Keeping uptodate with latest developments in immunology by reading literature and attending conferences
- Contribute ideas and suggestions to all DJS programs
- Gather analyse and present data from a variety of sources to the wider team and organization
- Critical and impartial review of self and peergenerated laboratory data to create tangible actions
- Maintenance of laboratory experimental records
Qualifications :
Applicants required attributes
- A PhD in Immunology or a related field or equivalent level of experience
- Have a passion for immunology and translational biology
- Enthusiasm and commitment to drug development research
- Willingness to work with human tissue samples under an HTA
- Proven expertise and experience in:
- Establishing in vitro models for inflammatory disorders
- Secondary ex vivo cellbased assays (such as for example FACS/cell sorting imaging ELISA/MSD Westernblot and omicsbased approaches such as RNAseq)
- Statistical analysis power calculations and experimental design
- Establishing primary cell assays and developing them for reproducible high throughput screening
Applicants desirable characteristics
- Working with preclinical models for therapeutic antibody development
- Have previously held a UK PIL licence (or equivalent) with experience in executing in vivo studies in preclinical models
- Building and maintaining collaborative networks across multiple organizations
- Working within an industrial setting on a drug development program
- Working with organoids or organ on a chip models
- Working with contract research organisations
- Antibody binding techniques; ELISA FACS SPR etc.
- Evidence of excellent organizational and interpersonal skills including:
- work both independently and as part of a team
- Ability to work efficiently with strong attention to detail
- Ability to build effective working relationships within large organizations and across different time zones
- Ability to work flexible hours when required
- Proven written and oral communicative ability
- Problemsolving skills
- Flexible and adaptable with an allinclusive goalorientated mindset
- Working under a Human Tissue Authority license
Additional Information :
AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives serving our community and embracing diversity and inclusion. It is AbbVies policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race color religion national origin age sex (including pregnancy) physical or mental disability medical condition genetic information gender identity or expression sexual orientation marital status status as a protected veteran or any other legally protected group status.
US & Puerto Rico only to learn more visit & Puerto Rico applicants seeking a reasonable accommodation click here to learn more:
No
Employment Type :
Fulltime
Employment Type
Full-time
