PhD Student position Quantitative Spatial Cancer Biology research group
PhD Student position Quantitative Spatial Cancer Biology research group
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Job Description
We are seeking a highly motivated PhD Student to join our Quantitative Spatial Cancer Biology research group at the Dr. Senckenberg Institute of Pathology and the Mildred Scheel Career Center (MSNZ) Frankfurt an excellence program supporting careers in translational cancer research (funded by the German Cancer Aid). The lab headed by Dr. Konstantinos Kokkaliaris specializes in hematopoietic stemcell biology and bone marrow tissue organization in health aging and cancer. We use innovative singlecell protein profiling technologies including cuttingedge multiplex 3D tissue imaging multicolor flow cytometry and mass cytometry. The focus of the lab is to better understand tissue organization in homeostasis aging and disease as well as further develop multiplex tissue imaging modalities. We are looking for a candidate interested in deciphering the crosstalk mechanisms through which malignant cells interact and shape their local tissue microenvironment to favor disease progression at the expense of healthy tissue function using singecell technologies and in vivo models.
Further information on the lab can be found here: description:
The project aims to define the key cellular molecular and structural alterations in the bone marrow in hematologic malignancies and following response to induction chemotherapy. We will focus on targetable interactions between (malignant) cells and their spatial tumor microenvironment(s) to overcome therapy resistance while enhancing healthy tissue recovery and function. Our goal is to leverage those findings towards designing and functional validation of novel therapeutic intervention strategies for longer diseasefree survival against lethal hematologic malignancies including acute myeloid leukemia.
Relevant Publications:
Hofmann J. and Kokkaliaris KD. Bone marrow niches for hematopoietic stem cells: life span dynamics and adaptation to acute stress. Blood. 2020; 144 1: 2134.
Kokkaliaris KD and Scadden DT. Cell interactions in the bone marrow microenvironment affecting myeloid malignancies. Blood Advances. 415:. (Cover story)
Kokkaliaris KD* Kunz L CabezasWallscheid N Christodoulou C Renders S Camargo F Trumpp A Scadden DT Schroeder T*. Adult blood stem cell localization reflects the abundance of reported bone marrow niche cell types and their combinations. Blood. 2020; 13620:. *cocorresponding authors (Cover story)
Coutu D Kokkaliaris KD Kunz L Schroeder T. Multicolor quantitative confocal imaging cytometry. Nature Methods 2018; 15: 3946. cofirst authors
Coutu D Kokkaliaris KD Kunz L Schroeder T. Threedimensional map of nonhematopoietic bone and bonemarrow cells and molecules. Nature Biotechnology 2017; 3512:. cofirst authors (Cover story)
- Masters degree in life sciences biology or equivalent
- Experience in basic laboratory techniques (i.e. molecular biology)
- Passion for discovery collaborative spirit & good communication skills
- Previous experience in immunofluorescence staining flow cytometry and imaging is a plus
- Felasa accreditation or previous experience with animal models is a plus
- Proficiency in spoken and written English
- Due to legal regulations valid proof of measles immunity / measles vaccination is required.
- Scientific Environment: Excellent scientific environment & dedicated mentoring training on cuttingedge singlecell technologies
- Collaboration: Collaboration opportunities with national & international expert laboratories
- Mobility: Free public transport in all Hessen (Free State Ticket Hessen)
- Training: Participation in training and qualification programs of the MSNZ and the Goethe University
- Collective agreement: The position 65 E 13 is initially limited for 3 years with the possibility for extension
- WorkLifeBalance: Parttime employment is possible we offer childcare in our daycare center (if you have any questions please contact UKFFamilienservice) child care during holidays
- Campus: Our attractive university hospital campus offers a modern cafeteria various cafes and opportunities to rest in numerous green spaces. A walk on the riverside of the Main offers relaxation during breaks
- Health Promotion: Benefit from our attractive health offers. We offer regular online and facetoface courses on nutrition relaxation sports and exercise.
Contact: Dr. Konstantinos Kokkaliaris
Mail:
application deadline: May9th 2025
Application documents: CV short motivation statement 1 page maximum) and one reference letter
We are targeting applicants of all genders and nationalities. Applicants with handicap will be preferred if personal and professional skills are equivalent.
Employment Type
Full-Time
