Postdoctoral Fellow Respiratory Immunology Early Drug Discovery Research
Postdoctoral Fellow Respiratory Immunology Early Drug Discovery Research
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Job Description
Position: Postdoctoral Fellow Respiratory & Immunology Early Drug Discovery Research
Location: Gaithersburg US
Department: Biopharmaceuticals
Our Postdoc Programme is for selfmotivated individuals looking to take on interesting high impact projects in a collaborative challenging and reputable environment. Do you have expertise in and passion for respiratory disease understanding Would you like to apply your knowledge to impact drug discovery projects in a company that follows the science and turns ideas into lifechanging medicines Then join the Respiratory & Immunology Group at AstraZeneca and unlock the power of what science can do.
Therapeutic Area Description:
With five decades of experience we are an established leader in respiratory care and a disruptor in immunology. We are committed to transforming care for some of the most debilitating and chronic respiratory and immunemediated diseases. Our portfolio of inhaled and biologic medicines and our pipeline for the future seek to address the challenges and vast unmet medical needs patients face today. By following the science we are focused on sustainably addressing tough and complex unsolved problems. Our approach involves targeting the underlying biology developing effective new drug modalities and combinations and applying a precision medicine approach from the start of discovering medicines all while driving earlier detection diagnosis and intervention.
Academic Supervisor:
Professor Mauricio Rojas
Vice Chair of Research Department of Internal Medicine Professor
201 Davis Heart & Lung Research Institute
473 W. 12th Avenue
Columbus OH 43210
We are seeking a candidate with a Ph.D and/or M.D./Ph.D degree who has a broad understanding of the pathophysiological mechanisms underlying respiratory diseases such as Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis. This candidate would be expected to demonstrate a passion for innovative scientific research leading to the discovery and development of novel therapeutics.
What is the purpose of this position
Human lung has a complex architecture where structural cells interact continuously with immune cells that infiltrate into the pulmonary most of the studies on the deleterious effects of smoke and pollutant exposures have been done in epithelial cells and the contribution of immune cells like macrophages or supporting mesenchymal to epithelial injury in COPD has been neglected. The main focus of this position is understanding the role of macrophages in injury and repair processes in the lung which may inspire new clinical strategies for promoting regeneration from remaining endogenous stem cells in damaged lungs in COPD. Youll be wellsupported by a passionate and highly experienced team of industryleading experts within AstraZeneca along with support from academic leaders in the field of respiratory and immunology research.
Whats Involved in the Role
Understanding the role of Macrophages in COPD disease.
The daytoday life of our postdoctoral fellow will be dynamic and intellectually stimulating. Youll typically spend a significant portion of your time in the lab conducting experiments related to their projects. These projects are aligned with AstraZenecas research focus areas and may involve investigating potential drug candidates and exploring new therapeutic targets.
You will collaborate with fellow scientists and crossfunctional teams within the department.
These collaborations offer opportunities for knowledgesharing idea brainstorming and gaining insights from experienced professionals including leading authorities in precision medicine and bioinformaticians.
Furthermore the postdoc will be expected to attend regional and national conferences and publish in highimpact peerreviewed journals and this experience will further boost the candidates academic and professional profile.
Collaborations:
You will collaborate with fellow scientists and crossfunctional teams within the department.
These collaborations offer opportunities for knowledgesharing idea brainstorming and gaining insights from experienced professionals including leading authorities in precision medicine and bioinformaticians.
In collaboration with Dr. Mauricio Rojas we have previously investigated COPD heterogeneity. You will continueto collaborate with his team at Ohio State University. Dr. Rojas is a pioneer in lung research and this collaboration offers you a great opportunity to learn more about themechanism of lung repair and critical factors involved in the vulnerability to lung diseases.
Essential Qualifications / Education:
A PhD or equivalent in Immunology or Molecular Biology in research background
A maximum of 4 years of postdoctoral experience.
Effective implementation of standard molecular biology lab assays and in vitro cell culture to answer research questions.
Extensive knowledge of immunology and lung biology
Publication record of novel and impactful research
Desirable Skills Experience & Behaviours:
Experience with complex dataset analysis and exploration.
Experience with human primary cell cultures and 3D tissue models.
Experience with macrophage and neutrophil culture.
Great enthusiasm for novel exploratory research
Personal Characteristics & Behaviours:
Outstanding verbal and written communication skills.
Proficient in problemsolving and the design of experiments.
Collaborate and work well with others.
Where Can I Find Out More:
AstraZeneca Respiratory & Immunology: Rojas: Postdoc Programme: at AstraZeneca: Open Date: Apr 10 2025
Req Close Date: May 11 2025
Stages of interview: Applicants are reviewed for fit/skills and invited to each step. You may not be invited to each step. 1 Oneway video interview and 2
Virtual Interview Panel with presentation.
To find out more go to: astrazeneca and anticipate a high volume of applicants so do not delay applying today!
Compensation for this role depending on years of research experience is a minimum of US$96000 up to Max of US$104000 shortterm incentive. Some relocation supplements depend on distance and location at the employers discretion.
Date Posted
11Apr2025Closing Date
11May2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion starting with our recruitment process. We welcome and consider applications from all qualified candidates regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations please complete the section in the application form.Employment Type
Full-Time
