UNIV - Post Doc - Department of Neurosurgery

Job Description Summary

The laboratory of Dr. Strickland in the Department of Neurosurgery and Cancer Biology & Immunology at MUSC is recruiting a motivated postdoctoral fellow in the field of central nervous system immunooncology. The Strickland lab focuses on targeting immunosuppressive tumor associated macrophage (TAM) as a means of antitumor therapy against glioblastoma. The major theme is translating methods of TAM depletion or reprogramming towards an antiinflammatory phenotype into clinical trial in Dr. Stricklands busy clinical practice. Dr. Stricklands laboratory leverages syngeneic animal models with highthroughput transcriptomic approaches to elucidate the complex glioblastoma microenvironment and develop targeted therapies. Studies will generally range from single cell/nuclei and spatial transcriptomics/proteomics functional cellbased assays mouse models and human invitro cell culture. In this position you will have the opportunity to develop and lead projects focused on targeting macrophages in glioblastoma with an emphasis on developing a novel target for CART delivery. You will also gain experience and training in transcriptomics/proteomics preclinical study development. As such the ability to work with mouse models of cancer is essential. A successful postdoctoral research fellow would be expected to conduct high quality research for publication in high impact journals. Fellows would also be encouraged to apply for independent postdoctoral grants. The Fellow would be joining a laboratory with an experienced research technician III.

Entity

Medical University of South Carolina (MUSC Univ)

Worker Type

Employee

Worker SubType

Regular

Cost Center

CC000986 COM NSGY General CC

Pay Rate Type

Salary

Pay Grade

University00

Pay Range

0.00 0.00 0.000

Scheduled Weekly Hours

40

Work Shift

Job Description

Job Duties:

35 Develop and lead projects using several cuttingedge model systems including TAM depletion TAM reprograming and immune competent models of malignancy. Analyze data generated from these studies and prepare manuscript drafts and present at national conferences.

35 Train in transcriptomics flow cytometry adoptive transfer biology and preclinical development and preparation of IND enabling documents. Outcomes will lead to a publishable manuscript.

25 Perform immunology techniques including ELISAs flowbased cytokine determination cellular proliferation and cytotoxicity assays conduct collaborative work on multiinstitutional grants.

5 Perform other essential duties as requested. These will include maintain animal colonies collaborate with DLAR to provide the best animal care update IACUC and IBC protocols order supplies for the laboratory.

Additional Job Description

MUSC Minimum Training and Experience Requirements: PhD

Preferred Experience & Additional Skills: Successful applicants will have a Ph.D. or M.D./Ph.D. with substantial handson research experience in immunooncology. Candidates with prior experience in immunology immunotherapy tumor microenvironment and cancer biology are highly desirable for this position. As this position will involve in vivo mouse models of glioblastoma experience in techniques such as animal handling drug administration multicolor flow cytometry ELISA flowbased cytokine determination cytometric bead array TCR immunesequencing and cellbased bioassays are essential. A familiarity with handling large data sets to investigate immune pathways dysregulated in glioblastoma and immunotherapyresistant tumors is also desirable. The candidate must be fluent in oral and written English able to work independently and collaboratively are well organized proficient of proper scientific record keeping be able to analyze and interpret/communicate data in a logical and timely manner. The ideal candidate will also be able to work with the fluctuating schedule of the neurosurgeon PI who commands a busy brain tumor center.

Physical Requirements: (Note: The following descriptions are applicable to this section: Continuous 68 hours per shift; Frequent 26 hours per shift; Infrequent 02 hours per shift) Ability to perform job functions in an upright position. (Continuous) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb stairs. (Infrequent) Ability to work indoors. (Continuous) Ability to work in all cold temperature extremes i.e. spot coolers. (Frequent) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to perform pinching operations. (Continuous) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Continuous) Ability to fully use both legs. (Continuous) Ability to reach in all directions. (Continuous) Possess good finger dexterity. (Continuous) Ability to maintain tactile sensory functions. (Continuous) Ability to maintain good olfactory sensory function. (Continuous) Ability to lift and carry 15 lbs. unassisted. (Frequent) Ability to lift objects up to 15 lbs. from floor level to height of 72 inches unassisted. (Frequent) Ability to lower objects up to 15 lbs. from height of 72 inches to floor level unassisted. (Frequent) Ability to push/pull objects up to 15 lbs. unassisted. (Infrequent) Ability to lift and carry objects up to 15 lbs. a distance of five 5 floors and to outlying buildings. (Frequent) Ability to maintain 20/40 vision corrected. (Continuous) Ability to see and recognize objects close at hand. (Continuous) Ability to see and recognize objects at a distance. (Continuous) Ability to match or discriminate between colors. (Continuous) Ability to determine distance/relationship between objects; depth perception. (Continuous) Good peripheral vision capabilities. (Continuous) Ability to maintain hearing acuity with correction. (Continuous) Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to be qualified physically (by medical personnel) for respirator use initially and annually. Ability to work alone in isolated areas such as darkrooms. (Frequent)

Additional New Requirements: Ability to obtain and maintain a valid drivers license. Computer literacy. Ability to work rotating shifts as required. Ability to work overtime as required. Ability to learn and use new processes tools and equipment as required.

If you like working with energetic enthusiastic individuals you will enjoy your career with us!

The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race color religion or belief age sex national origin gender identity sexual orientation disability protected veteran status family or parental status or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications merit and business need.

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