Senior Research Scientist Translational Medicine Multiple Myeloma Immuno-Oncology
Senior Research Scientist Translational Medicine Multiple Myeloma Immuno-Oncology
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$ 153935 - 199210
1 Vacancy
Job Description
Were here for one reason and one reason only to cure cancer. Every moment is dedicated to developing treatments and every action moves us one step closer to our goal. Weve made incredible scientific breakthroughs and our pioneering personalized CAR Tcell therapies have changed the paradigm. But were not finished yet.
Join Kite as we make even bigger advances in cancer therapies and help shape where our business and medical science goes next.
We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future you are the key driver in evolving our culture and creating an environment where every employee feels included developed and empowered to fulfil their aspirations. Join Kite and help create more tomorrows.
Job Description
Summary
The Senior Scientist will design and execute multiomics biomarker analyses pertinent to multiple myeloma and other hemeoncology indications.
As a member of the Translational Medicine team you will be at the intersection of Research and Clinical Development providing valuable insight into the function and safety of CART cells the investigation of mechanisms of action response relapse and toxicity and the development of potential prognostic and predictive tools supporting pipeline advancement and informing design of next generation therapeutics and clinical development of Kites chimeric antigen receptor (CART) programs.
Essential requirements are a solid understanding of cancer biology and immune therapy a strong understanding and expertise with multiomics analytical methods (eg scRNAseq Proteomics Metabolomics flow cytometry Spatial transcriptomics) and downstream computational data processing data interpretation and reporting demonstrated by education previous professional experience and authorship in highimpact scientific communications/publications. Familiarity with cloud computing platforms such as AWS and/or highperformance computing (HPC) environments is preferred.
Key Responsibilities:
- Collaborates with analytical teams within translational medicine and crossfunctionally for planning and of correlative studies around disease biology drug mechanisms of action and mechanisms of response relapse and toxicity.
- Oversees directs and establishes the computational analytical workflows.
- Writes reviews leads and/or contributes to research reports and all projectrelated documents as needed.
- Contributes and leads internal and external scientific presentation discussions/collaborations and publications and engages with key internal stakeholders.
- Leverages cloud based or HPC infrastructure for scalable processing of largescale multiomics datasets.
Basic / Essential Qualifications
Bachelors Degree and 8 years of scientific experience
OR
Masters Degree and 6 years of scientific experience
- Strong background in cancer biology and immunooncology and/or immunology (or closely related field)
- Strong understanding of clinical translational and mechanistic data
- Strong expertise in analysis of large multiomics datasets including proteomics transcriptomics and other genomic analyses (eg scRNAseq WES ATACseq) using computational methods (eg R programing Python) and Machine Learning to profile disease biology and immune cell repertoire.
- Strong collaboration excellent interpersonal and communication skills
- Proficient with data presentations to communicate to a diverse crossfunctional audience.
- Maintain a high degree of accuracy and attention to details.
Preferred Qualifications:
- Ph.D. degree in Immunooncologyrelated field (cancer biology immunology bioinformatics or a closely related field)
- Experience with cloudbased data storage pipeline deployment and computation using platforms such as AWS or HPC etc.
- Experience working with engineered T cells
- Understanding of early and/or latestage drug and translational development process; including prior clinical trial experience in industry or academia
- Direct experience and/or in depth understanding of an array of analytical methods such as NGS methods flow cytometry ELISA or other ligandbased immuneassay IHC/IF ddPCR FISH.
- Comfortable in a matrixed and fastpaced company environment and able to adapt to changing priorities
- Understanding of clinical landscape evolving therapy competitive scenarios in the immuneoncology space
- Handson experience analyzing proteomics and/or metabolomics data sets is preferred.
- Familiarity with workflow management systems (e.g. Nextflow Snakemake) and reproducible analysis tools (e.g. Docker GitHub)
For additional benefits information visit:
Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment and is dedicated to fostering an inclusive work environment comprised of diverse perspectives backgrounds and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race color religion national origin sex age sexual orientation physical or mental disabilitygenetic information or characteristic gender identity and expression veteran status or other nonjob related characteristics or other prohibited grounds specified in applicable federal state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973 the Vietnam Era Veterans Readjustment Act of 1974 and Title I of the Americans with Disabilities Act of 1990 applicants who require accommodation in the job application process may contact for assistance. NOTICE: EMPLOYEE POLYGRAPH PROTECTION ACT PAY TRANSPARENCY NONDISCRIMINATION PROVISION Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team. Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion. Please apply via the Internal Career Opportunities portal in Workday.
Kite is a biopharmaceutical company engaged in the development of innovative cancer immunotherapies with a goal of providing rapid longterm durable response and eliminating the burden of chronic care. The company is focused on chimeric antigen receptor (CAR) and T cell receptor (TCR) engineered cell therapies designed to empower the immune systems ability to recognize and tumors. Kite is based in Santa Monica CA. For more information on Kite please visit . Sign up to follow @KitePharma on Twitter at jobs in the United States:
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Required Experience:
Senior IC
Employment Type
Full-Time
