Senior Scientist Next Generation Medicine Design
Senior Scientist Next Generation Medicine Design
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Job Description
Working with Us
Challenging. Meaningful. Lifechanging. Those arent words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here uniquely interesting work happens every day in every department. From optimizing a production line to the latest breakthroughs in cell therapy this is work that transforms the lives of patients and the careers of those who do it. Youll get the chance to grow and thrive through opportunities uncommon in scale and scope alongside highachieving teams. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits services and programs that provide our employees with the resources to pursue their goals both at work and in their personal lives. Read more: targets and modalities that have historically provided rich opportunities for drug discovery and decades of productive academic and industrial research are gradually giving way to new scientific frontiers. A steady shift is underway in the target and modality landscape with novel approaches such as targeted protein degradation emerging as particularly exciting and rapidly evolving areas of research.
We seek exceptional scientists who are highenergy innately curious selfstarters with versatile skill sets and the capacity to thrive in a dynamic fastpaced research environment. Joining the New Leads and Computational Sciences team you will drive our Protein Homeostasis portfolio by leveraging structurebased and ligandbased computational chemistry methods data visualization data analysis and advanced machine learning and AI techniques. Your goal will be to design molecules demonstrating superior degradation profiles and pharmacological properties.
In close collaboration with multidisciplinary Protein Degrader project teams you will proactively generate and test scientific hypotheses design and execute sophisticated computational experiments deliver thorough analyses interpret experimental outcomes and translate insights into actionable molecular designs that meaningfully advance our discovery programs. Your technical expertise clear communication skills and collaborative approach will enable you to effectively partner with scientists across the R&D organization significantly influencing the pipeline from target identification through degrader optimization to candidate nomination.
Responsibilities will include but are not limited to the following:
Lead and influence the strategic application of computational methods to rigorously evaluate therapeutic targets protein degradation modalities and novel degrader designs within multidisciplinary project teams.
Develop and apply a diverse suite of computational chemistry methods to optimize molecules for potency selectivity protein degradation efficiency and favorable ADME properties while proactively identifying and mitigating potential toxicological risks.
Partner closely with experimental and project scientists to drive informed decisionmaking ensuring computational insights directly support and accelerate project objectives.
Utilize structural modeling artificial intelligence (AI) machine learning (ML) statistical analysis and data visualization techniques to deepen structureactivity relationship (SAR) insights contributing actively to project strategy and decisionmaking processes.
Innovate and apply advanced multiparameter optimization approaches to identify and enhance biologically relevant molecular features ensuring optimal therapeutic profiles.
Provide strategic scientific leadership in target validation and assessment activities including comprehensive literature and patent reviews competitive intelligence gathering chemical feasibility evaluations and indepth characterization of target druggability and binding site properties.
Maintain expertise and continually expand your proficiency in stateoftheart computational chemistry methods actively exploring and implementing emerging technologies to enrich and advance our discovery pipeline.
Background Requirements:
A completed Ph.D. in computational chemistry or a related field with strong application background as demonstrated by contributions to leading journals
A minimum of 5 years of biotech/pharmaceutical industrial experience.
Demonstrated expertise in a subset of computational methods such as: docking methods structurebased drug design ligandbased drug design molecular dynamics simulations homology modeling approaches free energy simulations machine learning techniques statistical methods largescale data visualization/analysis molecular matched pair analyses or multiple parameter optimization methods.
Demonstrated experience applying computational chemistry methods to a variety of biological targets (e.g. proteins DNA RNA). Familiarity with diverse therapeutic modalities is preferred such as: covalent/noncovalent inhibitors allosteric modulators targeted protein degraders antibodies antibodydrug conjugates etc.
Scientific/Technical/Functional Skills:
Proven expertise in computerassisted drug design proficiently utilizing industrystandard modeling and computational chemistry software tools.
Ability to independently review scientific literature and project data creatively formulate design hypotheses conduct insightful data analyses and design innovative molecular agents tailored to project goals.
Demonstrated ability to serve as an independent computational chemist on discovery teams proactively driving projects and ensuring timely achievement of scientific milestones.
Solid working knowledge of medicinal chemistry principles and drug discovery processes.
Familiarity with at least one scripting or programming language (e.g. Python R Java C).
Strong interpersonal organizational and communication skills with a collaborative mindset that thrives in multidisciplinary and geographically dispersed project teams.
Scientific integrity curiosity creativity proactive problemsolving abilities and a high degree of motivation and work ethic.
If you come across a role that intrigues you but doesnt perfectly line up with your resume we encourage you to apply anyway. You could be one step away from work that will transform your life and career.
Uniquely Interesting Work Lifechanging Careers
With a single vision as inspiring as Transforming patients lives through science every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture promoting global participation in clinical trials while our shared values of passion innovation urgency accountability inclusion and integrity bring out the highest potential of each of our colleagues.
Onsite Protocol
BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes siteessential sitebydesign fieldbased and remotebydesign jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:
Siteessential roles require 100 of shifts onsite at your assigned facility. Sitebydesign roles may be eligible for a hybrid work model with at least 50 onsite at your assigned facility. For these roles onsite presence is considered an essential job function and is critical to collaboration innovation productivity and a positive Company culture. For fieldbased and remotebydesign roles the ability to physically travel to visit customers patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application or in any part of the recruitment process direct your inquiries to . Visit to access our complete Equal Employment Opportunity statement.
BMS cares about your wellbeing and the wellbeing of our staff customers patients and communities. As a result the Company strongly recommends that all employees be fully vaccinated for Covid19 and keep up to date with Covid19 boosters.
BMS will consider for employment qualified applicants with arrest and conviction records pursuant to applicable laws in your area.
If you live in or expect to work from Los Angeles County if hired for this position please visit this page for important additional information: data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
Required Experience:
Senior IC
Employment Type
Full-Time
