Scientist IScientist II Chemical Development

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery development and commercialization of targeted protein degradation medicines the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AIintegrated discovery engine capable of tackling any protein class and coupled with unparalleled ligase expertise Nurixs dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degraderbased treatments at the forefront of patient care writing medicines next chapter with a new script to outmatch disease.

The candidate will be responsible for chemical developmentrelated activities across the portfolio including process development and manufacture of regulatory starting materials (RSMs) and supporting production of Drug Substance (DS) for clinical trial materials and establishment of associated control strategy for RSMs and DS to support CMC regulatory documents. The ideal candidate will be a highly motivated chemist with experience and interest in working in a small entrepreneurial environment with broad responsibilities and opportunities.

Principal Duties and Responsibilities

• Development of robust scalable and costeffective phaseappropriate manufacturing process that meet or exceed quality and regulatory requirements
• Work up to 50 of the time in the lab to support process route development and ongoing production campaigns
• Responsible for supporting RSMs and DS manufacturing related activities including scaleup of compounds to support internal and external drug development
• Author tech transfer documents and work with CROs/CDMOs to effectively and efficiently reproduce chemistry at various sites
• Support phaseappropriate process characterization identify critical quality attributes and implement controls including selection and justification of RSMs to ensure that all CROs and CMOs are using systems and processes in compliance with all relevant regulatory standards and to ensure consistency of DS quality
• Prepare review or edit technical reports protocols cGMP batch records CMC regulatory submissions and Quality documents
• Collaborate with crossfunctional teams including analytical chemistry formulation quality and regulatory to support drug development programs
• Travel up to 25

Skills and Background

• PhD with 2 years of experience or MS with 5 years of experience; advanced degree in Organic Chemistry Chemical Engineering Pharmaceutical Chemistry Pharmaceutics Pharmaceutical Science or related scientific discipline
• 13 years relevant experience in a pharmaceutical or biotechnology CMC/cGMP environment preferred
• Handson experience in multisteps organic synthesis. Familiarity with common analytical techniques (e.g. HPLC NMR mass spectrometry)
• Strong working knowledge of synthetic organic chemistry and the ability to leverage it toward route development and rapid synthetic triage
• Experience leveraging US and International CRO/CMOs for the manufacture of RSMs and DS to meet aggressive timelines
• Excellent problemsolving skills and the ability to identify resolve critical issues and work independently
• Experience implementing technical strategic and operational plans
• Excellent written and verbal communication skills exceptional interpersonal and management skills to collaborate with and direct the work of others on assigned projects (including both internal teams and external collaborators)
• Strongly team oriented

Nurix provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race color religion sex national origin age or genetics. In addition to federal law requirements Nurix complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment including recruiting hiring placement promotion termination layoff recall transfers leaves of absence compensation and training. Nurix expressly prohibits any form of workplace harassment based on race color religion gender sexual orientation gender identity or expression national origin age genetic information disability or veteran status. Improper interference with the ability of Nurixs employees to perform their job duties may result in discipline up to and including discharge.

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