Intern- Translational Medicine

Asklepios BioPharmaceutical Inc. (AskBio) is a leading clinicalstage gene therapy company founded in 2001 based on the work of adenoassociated virus (AAV) gene therapy visionary and pioneer Jude Samulski PhD. Since that time our commitment to developing lifesaving medicines that can potentially cure genetic diseases has never wavered.

At AskBio weve built a foundation of therapeutic programs AAV manufacturing and a rich portfolio of patented technology. Our therapeutic focus includes neuromuscular central nervous system cardiovascular and metabolic diseases with clinical trials underway for Pompe disease Parkinsons disease and congestive heart failure. Our gene therapy platform includes Pro10 an industryleading proprietary cell line manufacturing process and an extensive AAV capsid and promoter library.

We became a whollyowned independently operated subsidiary of Bayer AG in late 2020 as a cornerstone of its newly formed Cell & Gene Therapy (CGT) platform. Our global headquarters is in Research Triangle Park NC. Additionally we have significant operations in Philadelphia PA Columbus OH Scotland France Germany and Spain.

Our vision: Pioneering science to create transformative molecular medicines.

Our mission: Lead innovative science and drive clinical outcomes to transform peoples lives.

Our principles:

• Advance innovative science by pushing boundaries.

• Bring transformative therapeutics to patients in need.

• Provide an environment for employees to reach their fullest potential.

Our values:

• Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need.

• Cultivate Collaboration. Strive to be the best teammate actively listen openly communicate and embrace diverse points of view.

• Embrace Responsibility. We are humbled by the enormity of our mission.We hold a relentless commitment to advance science and clinical outcomes for our patients families and caregivers.

• Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action.

• Act with Uncompromising Integrity. Be honest transparent and committed to doing whats right in every situation. Make clear commitments and follow through.

Position Summary

We are looking for a motivated and enthusiastic Summer Intern to join our Bioanalysis & Bioassay team. The Intern Translational Medicine offers a unique opportunity to gain handson experience in cellbased assays for gene therapy products. The intern will contribute to the development of biomarker and biofunction detection assays to support earlystage research and development in CNS diseases. This position will allow the intern to build valuable expertise in bioassays and develop practical skills in CNS diseaserelated projects.

The intern will be based in RTP North Carolina and will report directly to a Senior Scientist in the Bioanalysis & Bioassay team.

Job Responsibilities

• Understand the mechanism of our CNS disease project

• Optimize the transduction efficiency in vitro cell model:

  • Design protocol of transduction steps on such as cell seeding density preparing AAV and reagents sample collection and detection method.

  • Help to select the most suitable cell model for the mechanism.

• Qualify the biomarker detection protocol:

  • Mechanismbased feasibility testing.

  • Evaluate the resource for further bioassay development.

• Present data the Bioanalysis & Bioassay team on a regular basis

Minimum Requirements

• Must be at least Junior in university pursuing a bachelors degree in Biology Molecular Biology or Life Sciences at the time of your application

Preferred Education Experience and Skills

• Prior internship work or volunteer/extracurricular experience

• Proficient with MS Office Suite and ability to learn new technologies quickly

• Excellent verbal and written communication skills

• Available to work fulltime during the summer months (MayAugust)

• Proactive and solutiondriven mindset

• Strong sense of accountability and ability to prioritize multiple tasks

• Excellent organizational skills and attention to detail

• Flexible and willing to support a variety of tasks for the (department) team

• Preferred some cell culture western blotting and ELISA experience

Asklepios BioPharmaceutical Inc. (AskBio) is an Equal Opportunity Employer and does not discriminate against any employee or applicant for employment because of race color religion gender sexual orientation gender identity national origin age disability veteran status or any other protected status prohibited under Federal State or local laws. All employment decisions are based on valid jobrelated requirements. If you are a qualified individual with a disability or a disabled veteran and are unable or limited in your ability to use or access our website you may request a reasonable accommodation to express interest in a specific opening by calling us ator sending us an email at .

Agencies: Please do not contact any employee at AskBio about this requisition. Any resume submitted by a recruitment agency to any employee at AskBio through any medium will be deemed the sole property of AskBio unless the agency was engaged by AskBio Talent Acquisition team to recruit for that position. All agencies must have a prior executed service agreement with AskBio prior to any search engagement. If a candidate who was submitted outside of the AskBio agency process is hired by AskBio no fee or payment of any kind will be paid to the agency.