Senti Bio is seeking a highly motivated and experienced Analytical Development Associate to support the buildout of Sentis analytical platforms. The successful candidate will contribute to the advancement of Sentis proprietary immunotherapeutic cell engineering platform focused on the development of key characterization and release assays. This role will mainly lead/support development and qualification of flow cytometry based assays with opportunities to support molecular and immunoassays as well. In parallel building CMC data for IND filings. The candidate will work closely with the QC group providing training writing documents and supporting method transfers. The candidate will be expected to collaborate with multiple groups independently perform experiments analyze data and present results.
Responsibilities
Supporting the development flow cytometry method particularly QC release assays
Creating and supporting the qualification of phenotype purity and expression panels
Create CMC data for IND filings and support writing of method development sections
Training of QC staff in preparation of tech transfer
As needed support development of immunoassays molecular and cellbased methods
Key contributor to researching investigating and implementing new technologies and methods
Mentor and supervise junior Associates
Independently perform experiments organize and analyze results
Successfully execute and document laboratory procedures and experiments with great attention to detail
Maintain accurate lab records and notebooks
Other duties as assigned
Qualifications
Bachelor or masters degree in Cell & Molecular Biology or related life science field
A minimum of 5 years of relevant experience analytical development industry experience is strongly preferred
Strong experience in development of flow cytometry methods
Experience with method qualification and transfer
Experience with tissue culture (adherent and suspension)
Experience with molecular and immunobased methods (qPCR dPCR ELISA) is a plus
Ability to multitask and meet deadlines in a fastpaced environment
Ability to think critically and demonstrate troubleshooting and problemsolving skills
Must be a team player proactive and willing to work in a small team environment
Must have excellent verbal and written communication skills
Proficient with MS office and other commonly used software and technology platforms
Selfmotivated and eager to take on temporary responsibilities outside of initial job description
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