Postdoctoral Fellowship
Postdoctoral Fellowship
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Job Description
Position: Postdoctoral fellowship Kimberly Laboratory
Project: To study neuroinflammatory mechanisms of bloodbrain barrier breakdown and secondary injury after stroke.The Kimberly Laboratory has an opening for a postdoctoral fellow to study mechanisms of poststroke neuroinflammation and its impact on bloodbrain barrier integrity. Recent studies in our laboratory have highlighted the importance of monocyte activation in MMP9 mediated BBB degradation and hemorrhagic transformation. Using pharmacologic probes in cell culture and animal models we are interested in understanding the role of ATP sensitive transporters in modulating inflammasome activation. Our studies suggest that inflammasome activation is a proximate event leading to MMP9 release BBB breakdown and hemorrhagic transformation.The overall thematic focus of the Kimberly Laboratory is to understand mechanisms of secondary neurological injury after stroke. We study mechanisms of hemorrhagic transformation and cerebral edema using cell model systems rodent animal models of stroke and human stroke patients focusing on common biological pathways shared among them. By understanding secondary neurological injury we hope to identify novel targets for treatment and discover biomarkers that may aid diagnosis and prognosis.
The Kimberly laboratory is located in a rich multidisciplinary environment involving clinicians bench scientists computational biologists and statisticians in the Center for Human Genetic Research which is located on the main campus of Massachusetts General Hospital in Boston MA.
Interested candidates should contact the principal investigator directly and include a current CV.W. Taylor Kimberly MD PhD
Mail: Massachusetts General Hospital Lunder 644 55 Fruit St Boston MA 02114 Tel:Email:
Employment Type
Full-Time
