Genesis Therapeutics is assembling a worldclass computational chemistry team to revolutionize drug discovery through cuttingedge machine learning and biophysical simulation. We are seeking a Principal CADD Scientist to join our onsite discovery team in San Diego working directly with scientists in our stateoftheart wet lab and with our distributed computational chemistry and CADD science teams across the US.
What You Will Do (Key Responsibilities)
Utilize a combination of industrystandard and proprietary AIpowered CADD tools to guide small molecule drug discovery programs across a diverse target portfolio including novel targets with limited chemical precedents.
Use approaches like virtual screening molecular simulation and potency and ADMET prediction to support key decisionmaking in drug discovery efforts.
Collaborate closely with medicinal chemists in molecular design and the development of projectspecific computational approaches.
Act as a crossteam connector effectively communicating between our computational chemistry and medicinal chemistry teams to ensure seamless information flow and collaborative decision making.
Adapt to a fastpaced environment where innovation and quick iteration are encouraged.
What youll bring
PhD in Computational Chemistry Structural Biology or a related field. This particular role may also be suitable for PhDlevel scientists with degrees in organic or medicinal chemistry with extensive experience in the lab who have transitioned into industry roles in CADD.
Deep understanding of structurebased drug design and proteinligand interactions.
Proficiency with industrystandard CADD tools such as MOE PyMOL and Schrodinger Suite.
Minimum of 5 years of industry experience as a CADD scientist in pharma or biotech with handson experience in active drug discovery programs.
What we offer
Competitive Pay
Health Care Plans (including Medical Dental and Vision fully covered for the employees)
Our team has created the industrys most advanced molecular AI platform called GEMS (Genesis Exploration of Molecular Space) to accelerate and optimize small molecule drug discovery and to enable the discovery of novel firstinclass and bestinclass small molecule for challenging and/or undruggable targets.
The company has leveraged GEMS to build an internal pipeline with multiple programs against highvalue targets including datapoor and canonically undruggable targets where GEMS is uniquely advantaged. In addition Genesis has signed AIfocused platform collaborations with major pharmaceutical companies including most recently Incyte Corporation (Feb 2025 and Gilead Sciences (Sept 2024.
We raised a $200M series B in August 2023 and have raised over $300M in funding from top technology and biotech investors including Andreessen Horowitz Rock Springs Capital T. Rowe Price Fidelity Radical Ventures NVentures (NVIDIAs VC arm) BlackRock and Menlo Ventures.
Genesis is headquartered in Burlingame CA with a fully integrated laboratory in San Diego. We are proud to be an inclusive workplace and an Equal Opportunity Employer.
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