Dmpk Biotransformation Postdoctoral Fellow
Dmpk Biotransformation Postdoctoral Fellow
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1 Vacancy
Job Description
Caringfor the world one person at a time has inspired and united the people ofJohnson & Johnson for over 130 years. We embrace research and science bringing innovative ideas products and services to advance the health andwellbeing of people.
With$76.5 billion in 2017 sales Johnson & Johnson is the worlds mostcomprehensive and broadlybased manufacturer of health care products as wellas a provider of related services for the consumer pharmaceutical andmedical devices markets. There are more than 250 Johnson & Johnsonoperating companies employing over 125000 people and with products touchingthe lives of over a billion people every day throughout the world. If you havethe talent and desire to touch the world Johnson & Johnson has the careeropportunities to help make it happen.
Johnson& Johnson is an Affirmative Action and Equal Opportunity Employer. Allqualified applicants will receive consideration for employment without regardto race color religion sex sexual orientation gender identity agenational origin or protected veteran status and will not be discriminatedagainst on the basis of disability.
JanssenResearch & Development L.L.C. a member of Johnson & Johnsons Familyof Companies is recruiting a motivated and enthusiastic individual to join theDMPK group as a Postdoctoral Fellow in San Diego CA to contribute to researchon druginduced liver injury (DILI) a significant reason for drug attrition.
A large body of evidence suggests that capableof forming reactive metabolites (RMs) are associated with DILI. The primaryresponsibility of the candidate is to study the formation of reactivemetabolites using novel in vitro systems combined with stateoftheart highresolution liquid chromatography tandem mass spectrometry (LCMS/MS) systems toenhance safety assessment for drug molecules particularly in the drugdiscovery setting. The candidate will conduct in vitro biotransformation studiesto determine the metabolic pathway mechanism and structural identity ofmetabolites. A key object of this position is to develop validate andimplement new assays and analytical methods (e.g.LCMS and data analysis) totranslate to positive clinical outcomes. The results from these studies willoffer new tools and insights for DMPK to better support drug discoveryprograms and findings will be encouraged to be published in scientificconferences and/or peerreviewed journals.- PhD degree in biochemistry medicinal chemistry analytical chemistry or other relevant discipline is required.
- Candidates must be available to work fulltime.
- Candidates must be legally authorized to work in the United States and not require sponsorship for employment visa status (e.g. H1B status) now or in the future.
- Previous small molecule LCMS/MS structural identification experience is required
- Good understanding of drug metabolism concepts is required
- Strong data analysis skills are desired
- Excellent interpersonal organizational oral/written communication and teamwork skills are required.
- Candidates must be detailoriented highly organized and able to manage multiple tasks.
- Candidates must have the ability to work individually (independently) as well as on a team.
- Record of accomplishment as evidenced by firstauthor and coauthored publications in scientific journals
Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religion sex sexual orientation gender identity age national origin or protected veteran status and will not be discriminated against on the basis of disability.
Employment Type
Grant
