Senior Scientist Molecular Pharmaceutics Drug Product Design
Senior Scientist Molecular Pharmaceutics Drug Product Design
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$ 88300 - 151500
1 Vacancy
Job Description
WHY PATIENTS NEED YOU
Pfizers purpose is to deliver breakthroughs that change patients lives. Research and Development is at the heart of fulfilling Pfizers purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences ensuring drug safety and efficacy or supporting clinical trials you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.
POSITION SUMMARY
As a Senior Scientist in the Molecular Pharmaceutics group you will act as a resident pharmaceutical science subject matter expert to influence small molecule early drug candidate selection with respect to drug delivery bioperformance and stability. This position will closely collaborate with colleagues across PharmSci as well as with partners in Medicinal Chemistry Pharmacokinetics & Drug Metabolism and Clinical Pharmacology. You will be responsible for designing implementing and interpreting in vitro in silico and in vivo experiments as well as design of stage appropriate traditional and enabled formulations for preclinical studies. This role will also specialize in formulation and characterization of spray dried dispersions (SDDs). An understanding of drug product development as well as an understanding of the disease state drug targets and drugtarget mechanisms of action will help to enable and narrow the definition of the required design elements. In additional to formulation you will be responsible for material science and physicochemical properties assessments of early drug candidates. This includes laboratory measurements and interpretation of the data to inform manufacturing bioperformance and stability development risks.
KEY RESPONSIBILITIES
Evaluate the physicochemical properties of potential small molecule drug candidates to inform a drug product formulation strategy and developability risk assessment
Design and develop fit for purpose and diagnostic traditional and enabled formulations for preclinical studies
Become a subject matter expert in formulation and process development for SDDs supporting multiple discovery teams across several research units
Design execute and interpret the results of polymorph and salt screens for potential drug candidates related to stability manufacturability and bioperformance
Apply first principles understanding of thermodynamics and kinetic processes to dissolution and precipitation of in biorelevant conditions and physical and chemical stability in the solid state.
Work in crossdisciplinary teams and partner with subject matter experts in Medicinal Chemistry Pharmacokinetics & Drug Metabolism and Clinical Pharmacology departments to influence candidate selection and progression. Develop strategic collaborations with academic and industrial researchers for addressing gaps in fundamental or applied science related to the pharmaceutical sciences
Conduct novel research and present significant findings via internal and external presentations or publications
MINIMUM QUALIFICATIONS
Recent PhD with 13 year postdoctoral experience MS with 7 years experience or BS with 8 years experience in Chemical Engineering Physical Chemistry Biophysical Chemistry Biophysics Physics Physical Organic Chemistry Pharmaceutics Pharmaceutical Sciences or Biochemistry
Candidates with experience in allied disciplines may also apply with the following qualifications: Ph.D. with minimum 3 years MS with 7 years or BS with 12 years of experience in industry
Experience working independently and collaboratively in a laboratory environment
PREFERRED QUALIIFICATIONS
Experience in formulation and manufacturing of SDDs targeted at bioavailability enhancement
Experience in breaking down and isolating the controlling physics of complex processes for experimental design
Experience in designing and conducting hypothesis driven laboratory experiments
Generating interpreting and integrating experimental data into mathematical models to progress the understanding of complex materials and processes
Experience in pharmacokinetic modeling and simulations using Gastroplus or similar modeling software
Experience with formulation design for preclinical studies as well as awareness of drug product design criteria for phase 1 clinical trials
Strong organizational skills interpersonal skills teamwork skills strong written and verbal communication skills
Ability to prioritize and manage multiple projects and activities while managing tight timelines
PHYSICAL/MENTAL REQUIREMENTS
Includes activities in both laboratory and office settings which would require varying degrees of sitting standing moving about the workspace light lifting working at a computer and performing routine laboratory tests and procedures. Also requires the ability to perform mathematical calculations and complex data analysis.
NONSTANDARD WORK SCHEDULE TRAVEL OR ENVIRONMENT REQUIREMENTS
Occasional travel may be requested. Laboratory work requires adherence to safe work practices and procedures such as use of Personal Protective Equipment (gowning gloves protective eyewear etc).
Work Location:On Premise with relocation support available as needed
The annual base salary for this position ranges from $88300.00 to $151500.00. In addition this position is eligible for participation in Pfizers Global Performance Plan with a bonus target of 12.5 of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of lifes moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution paid vacation holiday and personal days paid caregiver/parental and medical leave and health benefits to include medical prescription drug dental and vision coverage. Learn more at Pfizer Candidate Site U.S. Benefits (uscandidates.mypfizerbenefits). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care providers name address and the type of payments or other value received generally for public disclosure. Subject to further legal review and statutory or regulatory clarification which Pfizer intends to pursue reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse your name address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race color religion sex sexual orientation age gender identity or gender expression national origin disability or veteran status. Pfizer also complies with all applicable national state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an EVerify employer. This position requires permanent work authorization in the United States.
Required Experience:
Senior IC
Employment Type
Full-Time
