Research Fellow - Radiation Oncology
Research Fellow - Radiation Oncology
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Job Description
Postdoctoral Fellow Position in Particle Radiotherapy Radiobiology including DNA Damage Response Immunotherapy and Cancer Metabolism
Mayo Clinic Cancer Center Ebner/Hitosugi Laboratory
The Ebner/Hitosugi Laboratory at the worldrenowned Mayo Clinic Cancer Center is seeking a highly motivated Postdoctoral Fellow to join our dynamic team. Our research focuses on the utilization of high linear energy transfer radiotherapy including particle radiotherapy (proton carbonion others) and other methods of highLET radiotherapy delivery. Our focus includes the DNA damage response (with close collaborations in the Mutter/Lou laboratories) and radiobiologies inherent to this unique form of therapy interplay with antitumoral immunity and metabolomic evaluation of the full cellular response to combinatorial therapies. Our primary areas of focus are (osteo)sarcoma as well as head and neck malignancies incorporating particle beam radiotherapy DNA repair inhibitors immunotherapy and multiomic analyses including of clinical trial samples.
Who We Are
Our lab is a highly collaborative and innovative research environment led by experts in the field:
- Dr. Taro Hitosugi A world leader in cancer metabolism with an NIHfunded laboratory and highimpact publications.
- Dr. Daniel Ebner Physicianscientist specializing in Radiation Oncology with expertise in translational clinical trials and preclinical mechanistic research.
We work closely with top cancer biologists clinicians and global investigators at international radiotherapy centers to mechanistically understand the advantages of highLET radiotherapy (Bragg Peak protons carbonions alpha particles) with potential for beamtime delivery in Europe and Asia. Some of the key questions we explore include:
- How do traditionally treatment resistant cancers demonstrating poor immunotherapy response (such as osteosarcoma and head and neck cancers) respond to highLET radiotherapy and how might this generate therapeutic niches for targeted treatment amplification
- How do novel delivery methods of radiotherapy such as spatial fractionation augment and amplify these effects
- Taking a broad view of cancer response to radiation are there alternate paths by which we can target the cellular response to radiation
Your Role
As a Postdoctoral Fellow you will spearhead cuttingedge projects focusing on novel radiation techniques small molecule radiosensitizers and immunotherapy for sarcoma and head and neck cancers. Your research will involve:
- Stateoftheart experimental techniques including BP proton irradiation in murine tumor models in vitro alpha particle irradiation carbonion radiotherapeutic delivery in tandem with collaborators in Europe and Asia and advanced molecular biology methods.
- Multiomics and imaging approaches such as multiplexed immunofluorescence flow cytometry RNAseq wholeexome sequencing (WES) (phospho)proteomics metabolomics/metabolic tracing analysis and spatialomics in tumor models and patientderived tissues.
- Investigating how highLET radiation uniquely damages cancer cells leading to cancerspecific radiosensitization and enhanced immunotherapy responses.
Why Join Us
Joining the Ebner/Hitosugi Lab means becoming part of an environment that nurtures scientific growth and career development. We offer:
- Access to worldclass resources mentorship and training
- Opportunities to present at major conferences and collaborate globally
- A supportive environment where you can mentor and be mentored shaping the future of cancer research
Lab Culture
We thrive on teamwork diversity and innovation. Expect a collaborative and inclusive atmosphere with regular lab meetings social events and a shared commitment to advancing cancer research.
Qualifications
We seek candidates with a Ph.D. (or equivalent)in Cancer Biology Radiobiology DNA Damage/Repair Immunology Metabolism or a related field. Preference will be given to those who have at least one firstauthor publication in the relevant fields. Experience with the above technologies a plus as is prior coding experience (Python R and/or MatLab). The most important qualities we value are:
- A passion for scientific discovery
- Strong problemsolving skills
- Independence and drive for excellence
Employment Type
Full-Time
